Regeneration of the Living Pulp

Peralta, Tracy L. de

doi:10.1007/978-3-642-55160-4_17

Cited by 3 publications

(5 citation statements)

References 103 publications

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“…channel dp A U a n dx (1) where A is the generic cross-sectional area of the micro-channel and a is a dimensionless geometric factor. Classical derivations of the KC model [28,29] consider the case of a circular cross-section as a The permeability of porous media is usually expressed as a function of certain physical properties of the interconnected system, such as porosity and tortuosity.…”

Section: Numerical Proceduresmentioning

confidence: 99%

“…During the last few decades, clinical practice has been oriented towards the design and development of modern dental treatment techniques that would ensure the long-term maintenance of vitality and function of the dentine-pulp complex [1]. The traditional treatment strategies in vital pulp therapy have been mainly focused on protection of dental pulp from possible irritation presented by components released from dental materials and induction of replacement of diseased dentin by a layer of tertiary dentine [2].…”

Section: Introductionmentioning

confidence: 99%

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Computational Modelling for Efficient Transdentinal Drug Delivery

Passos

Tziafas

Mouza

et al. 2017

Fluids

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This work deals with the numerical investigation of the delivery of potential therapeutic agents through dentinal discs (i.e., a cylindrical segment of the dentinal tissue) towards the dentin-pulp junction. The aim is to assess the main key features (i.e., molecular size, initial concentration, consumption rate, disc porosity and thickness) that affect the delivery of therapeutic substances to the dental pulp and consequently to define the necessary quantitative and qualitative issues related to a specific agent before its potential application in clinical practice. The computational fluid dynamics (CFD) code used for the numerical study is validated with relevant experimental data obtained using micro Laser Induced Fluorescence (µ-LIF) a non-intrusive optical measuring technique. As the phenomenon is diffusion dominated and strongly dependent on the molecular size, the time needed for the concentration of released molecules to attain a required value can be controlled by their initial concentration. Finally, a model is proposed which, given the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tissue along with the aforementioned key design parameters, is able to estimate the initial concentration to be imposed and vice versa.

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Section: Numerical Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computational Modelling for Efficient Transdentinal Drug Delivery

Passos

Tziafas

Mouza

et al. 2017

Fluids

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show abstract

“…One of the most widely accepted and simplest model for the permeability-porosity relationship is the Kozeny-Carman (KC) model, which provides a link between media properties and flow resistance in pore channels. In this study we apply the general Poiseuille equation in a straight channel with a generic cross-sectional shape [26]: = − 1 channel dp A U a n dx (1) where A is the generic cross-sectional area of the micro-channel and a is a dimensionless geometric factor. Classical derivations of the KC model [27,28] consider the case of a circular cross-section as a starting point in Eq.…”

Section: Numerical Proceduresmentioning

confidence: 99%

“…During the last decades the clinical practice has been oriented towards the design and development of modern dental treatment techniques that would ensure the long-term maintenance of vitality and function of the dentine-pulp complex [1]. The traditional treatment strategies in vital pulp therapy have been mainly focused on protection of dental pulp from possible irritation presented by components released from dental materials and induction of replacement of diseased dentin by a layer of tertiary dentine [2].…”

Section: Introductionmentioning

confidence: 99%

Computational Modelling for Efficient Transdentinal Drug Delivery

Passos¹,

Tziafas²,

Mouza³

et al. 2017

Preprint

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This work deals with the numerical investigation of the delivery of potential therapeutic agents through dentinal discs (i.e. a cylindrical segment of the dentinal tissue) towards the dentin-pulp junction. The aim is to assess the main key features (i.e. molecular size, initial concentration, consumption rate, disc porosity and thickness) that affect the delivery of therapeutic substances to the dental pulp and consequently to define the necessary quantitative and qualitative issues related to a specific agent before its potential application in clinical practice. The CFD code used for the computational study is validated with relevant experimental data obtained using micro Laser Induced Fluorescence (μ-LIF) a non-intrusive optical measuring technique. As the phenomenon is diffusion dominated and strongly dependent on the molecular size, the time needed for the concentration of released molecules to attain a required value can be controlled by their initial concentration. Finally, a model is proposed which, given the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tissue along with the aforementioned key design parameters, is able to estimate the initial concentration to be imposed and vice versa.

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“…During the last decades the clinical practice has been oriented toward the design and development of modern dental treatment techniques that would ensure the long-term maintenance of vitality and function of the dentine–pulp complex (de Peralta and Nör, 2014 ). The traditional treatment strategies in vital pulp therapy have been mainly focused on protection of dental pulp from possible irritation presented by components released from dental materials and induction of replacement of diseased dentin by a dentin-like material (Tziafas et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms

et al. 2015

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The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated CFD code. In that framework we propose a simple algorithm that, given the type of molecules of the therapeutic agent and the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tubules, can estimate the initial concentration to be imposed.

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Regeneration of the Living Pulp

Cited by 3 publications

References 103 publications

Computational Modelling for Efficient Transdentinal Drug Delivery

Computational Modelling for Efficient Transdentinal Drug Delivery

Computational Modelling for Efficient Transdentinal Drug Delivery

Designing and testing regenerative pulp treatment strategies: modeling the transdentinal transport mechanisms

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