REGENERATION OF TdT+, PRE-B, AND B CELLS IN BONE MARROW AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION1

Asma, G. E. M.; Bergh, R Langlois Van Den; Vossen, Jaak M.

doi:10.1097/00007890-198706000-00019

Cited by 18 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because these donors had previously been infected with parvovirus B19 and were producing B19-specific antibodies, IgGproducing plasma cells are contained in the transplants. Thus, immunity to the transferred virus should be assumed, but antibody production is usually highly impaired in the first months after PBPC or BMT, 36 and symptomatic infection by this transmission route has been described. 23,37 In both allogeneic and autologous PBPCs, transmission of parvovirus B19 cannot be avoided by donor selection.…”

Section: Discussionmentioning

confidence: 99%

Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products

et al. 2005

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Glucocorticoids are widely used as anti-inflammatory drugs and there is some evidence that they suppress pre-B-cell numbers within bone marrow (51). Animal studies indicate that immature lymphocytes undergo apoptosis in response to such compounds (73), but it is not known if this has long term consequences for the immune system.…”

Section: Steroids May Regulate Human B-lymphocyte Productionmentioning

confidence: 99%

Early B-lymphocyte precursors and their regulation by sex steroids

et al. 2000

View full text Add to dashboard Cite

This review describes an improved characterization of early B-lymphocyte precursors in mice and the remarkable sensitivity of the same cells to hormones. The nuclear enzyme terminal deoxynucleotidyl transferase (TdT) was used as a marker to image and characterize bone marrow cells lacking all lineage-associated markers. Most early TdT+ precursors have a distinctive density of c-kit and express the interleukin-7Ralpha chain, as well as flt-3/flk2, but lack CD34. An understanding of those cell surface properties made it possible to obtain highly enriched, viable cells with the potential to give rise to CD19+ lymphocytes in culture. A series of other flow cytometry and culture experiments suggested a possible differentiation sequence for these early pro-B cells. This new model was used to advantage in our studies of sex steroids. It appears that early precursors represent a hormone-sensitive control point for determining numbers of new B lymphocytes that are produced within bone marrow. We also compare and contrast these findings with B lymphopoiesis in humans.

show abstract

Lack of B cell precursors in marrow transplant recipients with chronic graft-versus-host disease

et al. 1996

View full text Add to dashboard Cite

B cell reconstitution after bone marrow transplantation is slow in patients with chronic graft-vs.-host disease (cGVHD). Could this be secondary to decreased production of B cells in the bone marrow? We determined the relative amount of B cell precursors in the marrow of 26 patients at approximately 1 year after marrow transplant (10 patients with and 16 patients without clinical cGVHD) and 8 normal adult controls. In the controls (median), 3.1% of all marrow mononuclear cells were B cell precursors. The patients without cGVHD tended to have higher than normal percents of B cell precursors (median 6.5%; the difference from normal adults was not significant). In contrast, the patients with cGVHD had barely detectable B cell precursors (median 0.2%; the difference from normal adults was significant, P = 0.004). Therefore, delayed reconstitution of B cells in patients with cGVHD appears to be due at least in part to decreased B cell production by the marrow.

show abstract

REGENERATION OF TdT+, PRE-B, AND B CELLS IN BONE MARROW AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION1

Cited by 18 publications

References 0 publications

Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products

Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products

Early B-lymphocyte precursors and their regulation by sex steroids

Lack of B cell precursors in marrow transplant recipients with chronic graft-versus-host disease

Contact Info

Product

Resources

About