Regeneration of specific innervation inXenopus pectoralis muscle

Harada, Yuka; Grinnell, Alan D.

doi:10.1002/(sici)1097-4695(199612)31:4<433::aid-neu4>3.0.co;2-a

Cited by 2 publications

(1 citation statement)

References 48 publications

(33 reference statements)

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“…Stable π‐junctions have also been observed in adult muscles after neonatal treatment with neuromuscular blockers (Brown et al 1982) or hormones (Lubischer et al 1992), as well as in normal and reinnervated frog muscle (Werle & Herrera, 1987; Harada & Grinnell, 1996). These findings contrast, however, with those of Balice‐Gordon & Lichtman (1994) who showed that focal blockade of small fractions (< 20 %) of adult, mononeuronally innervated endplates with α‐bungarotoxin inevitably led to synapse withdrawal; and that during development, mononeuronal innervation is established by inexorable attrition of small, weak inputs (Coleman et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Co‐regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle

Costanzo

Barry

Ribchester

1999

The Journal of Physiology

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Activity exerts powerful, selective effects on the organisation, stability and strength of synaptic connections in all parts of the nervous system, including neuromuscular junctions (Lohof et al. 1996;Sanes & Lichtman, 1999). For example, neonatal rat muscle fibres are innervated at single motor endplates by motor nerve terminals supplied by several motoneurones (polyneuronal innervation; ð_junctions), and a similar pattern is re-established in adult muscle after nerve injury and regeneration (Brown et al. 1976;Betz et al. 1979;Ribchester, 1988). With time, synaptic boutons and axonal inputs are progressively eliminated, eventually leaving most endplates innervated by only one motor axon (Gan & Lichtman, 1998). Progressive and disproportionate weakening of synaptic transmission, induced by differences in pre-and postsynaptic activity, has been presumed to underlie this competitive process (Ribchester & Taxt, 1983;Balice-Gordon & Lichtman, 1994;Coleman et al. 1997). However, activity may not be sufficient to induce elimination from all ð_junctions. Previous studies of paralysed neonatal or reinnervated adult muscle suggest that significant polyneuronal innervation persists once activity resumes (Hoffman, 1953;Brown et al. 1982;Barry & Ribchester, 1995). The properties that allow convergent synapses of different size and efficacy to persist at a motor endplate are unknown. Equally, it is unclear whether apparently stable, convergent synaptic inputs in reinnervated muscles may in

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Section: Discussionmentioning

confidence: 99%

Co‐regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle

Costanzo

Barry

Ribchester

1999

The Journal of Physiology

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Activity-dependent switch from synapse formation to synapse elimination during development of neuromuscular junctions

Herrera

Zeng

2003

J Neurocytol

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The embryonic development of neuromuscular junctions consists of two successive epochs, an early period marked by exuberant synapse formation and a later period marked by synapse elimination. In the frog muscles we have studied, myogenesis is protracted and overlaps the periods of synapse formation and elimination. Thus, the formative and regressive events of synaptic development do not occur in synchrony across different fibers in the muscle. We propose that local activity orchestrates a shift from synaptogenesis to synapse elimination at the level of single muscle fibers. We also present evidence that perisynaptic Schwann cells and the expression of ion channels in the sarcolemma play important roles in the development of neuromuscular junctions. Questions for future study are outlined.

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Regeneration of specific innervation inXenopus pectoralis muscle

Cited by 2 publications

References 48 publications

Co‐regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle

Co‐regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle

Activity-dependent switch from synapse formation to synapse elimination during development of neuromuscular junctions

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