2020
DOI: 10.1177/2041731420974861
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Regeneration of skeletal system with genipin crosslinked biomaterials

Abstract: Natural biomaterials, such as collagen, gelatin, and chitosan, are considered as promising candidates for use in tissue regeneration treatment, given their similarity to natural tissues regarding components and structure. Nevertheless, only receiving a crosslinking process can these biomaterials exhibit sufficient strength to bear high tensile loads for use in skeletal system regeneration. Recently, genipin, a natural chemical compound extracted from gardenia fruits, has shown great potential as a reliable cro… Show more

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Cited by 55 publications
(50 citation statements)
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“…Many experiments have been performed in various fields, such as tissue engineering, to determine the antibacterial effects of nonantibiotic materials [7][8][9]. One of the nonantibiotic materials with antibacterial activity is a natural product.…”
Section: Introductionmentioning
confidence: 99%
“…Many experiments have been performed in various fields, such as tissue engineering, to determine the antibacterial effects of nonantibiotic materials [7][8][9]. One of the nonantibiotic materials with antibacterial activity is a natural product.…”
Section: Introductionmentioning
confidence: 99%
“…The polymerisation process occurred due to the helix-coil transition mechanism, which has been reported by Pattinelli et al [ 38 ] and Qiao et al [ 39 ]. In addition, the proposed crosslinking mechanism of action ( Scheme 1 ), that occurred between Gel and GNP, was stipulated and concluded with some modifications from previous articles that were published by Erdagi et al [ 40 ], Wang et al [ 41 ], Muzzarelli et al [ 42 ] and Liu et al [ 43 ], which explored the GNP abilities as a natural crosslinker.…”
Section: Discussionmentioning
confidence: 99%
“…Antibacterial effects are being studied in various fields, such as tissue engineering [ 7 , 8 , 9 ], and many experiments have been conducted to identify new substances that can target antibiotic-resistant bacteria. Recently, antimicrobial activity experiments using nanoparticles (NPs) have been actively conducted.…”
Section: Introductionmentioning
confidence: 99%