Regeneration of rabbit olfactory epithelium

Mulvaney, Bruce D.; Heist, Herbert E.

doi:10.1002/aja.1001310208

Cited by 99 publications

(33 citation statements)

References 9 publications

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“…Nonetheless, the degree of anatomic recovery in the olfactory epithelium overall after MeBr exposure is striking (Hurtt et al, 1988;Hastings et al, 1991;Schwob et al, 1995). Other models of epithelial damage, such as ZnSO 4 or nonionic detergent irrigation, give results that are similar in broad outline and in many of the details to the observations obtained by using MeBr (Mulvaney and Heist, 1971;Matulionis, 1975Matulionis, , 1976Harding et al, 1978;Nadi et al, 1981;Kream and Margolis, 1984;Burd, 1993).…”

supporting

confidence: 68%

Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation

et al. 1999

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supporting

confidence: 68%

Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation

et al. 1999

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“…It has been reported that basal cells in the olfactory epithelium are progenitors leading to the regeneration of new neuroepithelium (8,9,11,29), while others have suggested that the epithelial cells of Bowman's glands are progenitors for restoration of the olfactory epithelium (30,40). However, in this study, the progenitor cells involved in the restoration of the olfactory epithelium appeared to be the olfactory stem cells, which originate from basal cells rather than the epithelial cells of Bowman's glands.…”

Section: Test Atmosphere Generationcontrasting

confidence: 49%

Nasal Lesion Development and Reversibility in Rats Exposed to Aerosols of Dibasic Esters

1992

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This study was conducted to investigate the initial tissue damage, morphogenesis, and reversibility of nasal lesions induced by the inhalation of dibasic esters (DBE). Young male rats were exposed, nose-only, to an aerosol/vapor mixture of DBE at a concentration of 5,900 mg/m3 for 4 hr and subsequently killed at 1, 4, 7, 14, 21, and 42 days after exposure. Nasal lesions were distributed along major inspiratory airflow routes. Widespread epithelial denudation occurred in the anterior nasal cavity, but the lesions were confined to the dorsal meatus, adjacent the nasal septum, and the lateral middle meatus in the mid-anterior nasal cavity. The lesions were markedly less severe in the posterior nasal cavity and sharply confined to the tips of dorsal ethmoturbinates and adjacent nasal septum. The damaged cuboidal/nonciliated and respiratory epithelium in the anterior nasal cavity regained a normal structure by 4 and 7 days postexposure, respectively. The regeneration of damaged olfactory epithelium was related to the severity of initial tissue damage. Slightly damaged epithelium regained a normal appearance within 1-2 weeks, but the extensively denuded epithelium of the dorsal meatus in the anterior nasal cavity failed to regain a normal structure by 6 weeks. The sustentacular cells of the olfactory epithelium appeared to be the initial site of DBE nasal injury. In the early stages of regeneration, the epithelium was repaired by proliferating stem cells derived from basal cells. Numerous mitotic figures and bromodeoxyuridine labeling were found in the regenerating basal cells, stem cells, and sustentacular cells at 4 and 7 days. As repair processes advanced, the numbers of olfactory neurons and vesicles were increased with a proportional decrease in stem cells.

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“…Retroviral lineage analyses have confirmed that all neuronal progenitors of the ORN lineage (including, presumably, stem cells) reside in basal OE (Caggiano et al, 1994). Such studies have also contributed to the realization, derived initially from developmental and immunohistochemical experiments, that neither horizontal basal cells nor sustentacular cells are within the ORN lineage (Klein and Graziadei, 1983;Matulionis, 1976;Mulvaney and Heist, 1971).…”

Section: Progenitor Cells Of the Olfactory Receptor Neuron Lineage Nementioning

confidence: 74%

Progenitor cells of the olfactory receptor neuron lineage

Calof

Bonnin

Crocker

et al. 2002

Microscopy Res & Technique

130

114

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The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron lineage. The neuronal stem cell, which is ultimately responsible for continual neuron renewal in this system, gives rise to a transit amplifying progenitor identified by its expression of a transcription factor, MASH1. The MASH1-expressing progenitor gives rise to a second transit amplifying progenitor, the Immediate Neuronal Precursor, which is distinct from the stem cell and MASH1-expressing progenitor, and gives rise quantitatively to olfactory receptor neurons. Regulation of progenitor cell proliferation and differentiation occurs at each of these three cell stages, and growth factors of the fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) families appear to play particularly important roles in these processes. Analyses of the actions of FGFs and BMPs reveal that negative signaling plays at least as important a role as positive signaling in the regulation of olfactory neurogenesis.

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Regeneration of rabbit olfactory epithelium

Cited by 99 publications

References 9 publications

Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation

Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: Timing and extent of reinnervation

Nasal Lesion Development and Reversibility in Rats Exposed to Aerosols of Dibasic Esters

Progenitor cells of the olfactory receptor neuron lineage

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