Treatment of periodontal osseous defects; however, the clinical benefits of this therapeutic practice require further clarification through a systematic review of randomized controlled studies. The purpose of this systematic review is to access the efficacy of bone replacement grafts in proving demonstrable clinical improvements in periodontal osseous defects compared to surgical debridement alone. Several bone graft materials have been used in the treatment of infrasonic defects. Demineralized freeze-dried bone allograft (DFDBA) has been histologically proven the material of choice for regeneration. However, platelet-rich fibrin (PRF) has been said to have several properties that aid in healing and regeneration. Hence, this study focuses on the regenerative capacity of PRF when compared with DFDBA. This study was conducted as a case study in Russia (2021Russia ( -2022 and was presented at the Japan Dental Conference 2022.