Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli

Sarker, Md; Naghieh, Saman; McInnes, Adam D.; Schreyer, David J.; Chen, Daniel

doi:10.1016/j.pneurobio.2018.07.002

Cited by 153 publications

(132 citation statements)

References 220 publications

Supporting

Mentioning

132

Contrasting

Order By: Relevance

“…A previous study in our laboratory has demonstrated that OBC possesses a 3D network structure with nanoscale in fiber diameter, which facilitates cell adhesion and proliferation in vitro . Clinical evidence suggests that NGC with nano/microtopographical internal matrix improves peripheral nerve regeneration and functional recovery . Furthermore, nanofibrous structure has been proven to promote the differentiation of neural stem cells even without assistance of nerve growth factors .…”

Section: Discussionmentioning

confidence: 95%

Repairing Transected Peripheral Nerve Using a Biomimetic Nerve Guidance Conduit Containing Intraluminal Sponge Fillers

Hou

Wang

Zhang

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

Nerve guide conduits (NGCs) with geometric design have shown significant advantages in guidance of nerve reinnervation across the defect of injured peripheral nerves. It is realized that intraluminal fillers with distinctive structure can effectively provide an inner guidance for sprouting of axons and improve the permeability of NGC. In this work, a poly(lactic‐co‐glycolic acid) (PLGA) NGC is prepared containing intraluminal sponge fillers (labeled as ISF‐NGC) and used for reconstruction of a rat sciatic nerve with a 10 mm gap. For comparison, the same procedure is applied to a single hollow PLGA NGC (labeled as H‐NGC) and an autologous nerve. As evidenced by significantly improved nerve morphology and function, the ISF‐NGC achieves a superior nerve repair effect over H‐NGC, which is comparable to autologous nerve grafting. It is likely that the H‐NGC only provides a protected tunnel for nerve fiber regrowth and axonal extension, while ISF‐NGC offers an extracellular matrix‐mimetic architecture as autograft to provide contact guidance for nerve reinnervation. This newly developed ISF‐NGC is a promising candidate to aid nerve reinnervation across longer gaps commonly encountered in clinical cases.

show abstract

Section: Discussionmentioning

confidence: 95%

Repairing Transected Peripheral Nerve Using a Biomimetic Nerve Guidance Conduit Containing Intraluminal Sponge Fillers

Hou

Wang

Zhang

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…While chemical interactions can provide drugs immediately to cells or as cells proceed to grow within a scaffold, physical encapsulation of drugs provides a greater range of delivery options, such as long‐term or sustained release. Numerous molecules or drugs have been delivered to nerve for regeneration across a nerve defect, but the most researched category for delivery has been neurotrophic factors. Of these, glial cell line‐derived neurotrophic factor (GDNF) is a promising example that promotes regeneration because it targets both axons and SCs.…”

Section: Experimental Nerve Graft Alternativesmentioning

confidence: 99%

Advances in the repair of segmental nerve injuries and trends in reconstruction

2020

View full text Add to dashboard Cite

Despite advances in surgery, the reconstruction of segmental nerve injuries continues to pose challenges. In this review, current neurobiology regarding regeneration across a nerve defect is discussed in detail. Recent findings include the complex roles of nonneuronal cells in nerve defect regeneration, such as the role of the innate immune system in angiogenesis and how Schwann cells migrate within the defect. Clinically, the repair of nerve defects is still best served by using nerve autografts with the exception of small, noncritical sensory nerve defects, which can be repaired using autograft alternatives, such as processed or acellular nerve allografts. Given current clinical limits for when alternatives can be used, advanced solutions to repair nerve defects demonstrated in animals are highlighted. These highlights include alternatives designed with novel topology and materials, delivery of drugs specifically known to accelerate axon growth, and greater attention to the role of the immune system. K E Y W O R D S acellular nerve allograft, autograft, nerve gap, nerve guidance conduit, peripheral nerve 2 | BIOLOGY OF NERVE REGENERATION ACROSS A DEFECT Peripheral nerve is capable of robust regeneration following injury. The molecular and cellular mechanisms have primarily been studied in rodent models. Following injury, neurons and their axons and the nonneuronal cellular environment distal to the injury undergo immediate morphological and molecular changes. Within the axon, there is a rapid influx of ions, principally calcium, as well as a disruption of transport proteins signaling a disruption to homeostasis with its end-organ. This multifactorial injury response from axon damage is rapidly transported to the neuron cell Abbreviations: ANA, acellular nerve allograft; ECM, extracellular matrix; FDA, Food and Drug Administration; FK506, tacrolimus; GDNF, glial cell line-derived neurotrophic factor; GFRα1, glial cell line-derived neurotrophic factor family receptor alpha-1; MRC, Medical Research

show abstract

“…Although basic neuroscience continues to be the predominant focus in the field of axon regeneration, research focuses have also been placed on the development of bioengineered strategies that are clinically relevant to help patients who sustain neural injuries. For example, tissue engineering scaffolds made from biomaterials have combined both neuroscience and engineering approaches [26][27][28][29][30]. To this end, scaffolds are designed to act as structural supports for axonal growth and/or as vehicles for cell transplantation and drug delivery of therapeutic agents to promote nerve regeneration.…”

Section: Therapeutic Biomaterialsmentioning

confidence: 99%

Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

Chen

Auriat

et al. 2019

Processes

Self Cite

View full text Add to dashboard Cite

Development of biomaterials for the diagnosis and treatment of neurotraumatic ailments has been significantly advanced with our deepened knowledge of the pathophysiology of neurotrauma. Canadian research in the fields of biomaterial-based contrast agents, non-invasive axonal tracing, non-invasive scaffold imaging, scaffold patterning, 3D printed scaffolds, and drug delivery are conquering barriers to patient diagnosis and treatment for traumatic injuries to the nervous system. This review highlights some of the highly interdisciplinary Canadian research in biomaterials with a focus on neurotrauma applications.

show abstract

Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli

Cited by 153 publications

References 220 publications

Repairing Transected Peripheral Nerve Using a Biomimetic Nerve Guidance Conduit Containing Intraluminal Sponge Fillers

Repairing Transected Peripheral Nerve Using a Biomimetic Nerve Guidance Conduit Containing Intraluminal Sponge Fillers

Advances in the repair of segmental nerve injuries and trends in reconstruction

Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

Contact Info

Product

Resources

About