Regeneration of peripheral nerve through a polyglactin tube

Molander, Hårkan; Olsson, Yngve; Engkvist, Ove; Bowald, Staffan; Eriksson, I

doi:10.1002/mus.880050110

Cited by 191 publications

(47 citation statements)

References 13 publications

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“…Variations in the chemical and engineering properties of synthetic material are attractive, allowing alterations in the geometric configuration, biocompatibility, porosity, degradation, and mechanical strength (Lundborg and Hansson, 1980;Molander et al, 1982;da Silva et al, 1985;Langone et al, 1995;Aldini et al, 1996;den Dunnen et al, 1996). The variation in the above parameters can dramatically alter the ability of axons to proliferate.…”

Section: Scaffoldmentioning

confidence: 99%

Peripheral nerve injury: A review and approach to tissue engineered constructs

2001

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Eleven thousand Americans each year are affected by paralysis, a devastating injury that possesses associated annual costs of $7 billion (American Paralysis Association, 1997). Currently, there is no effective treatment for damage to the central nervous system (CNS), and acute spinal cord injury has been extraordinarily resistant to treatment. Compared to spinal cord injury, damage to peripheral nerves is considerably more common. In 1995, there were in excess of 50,000 peripheral nerve repair procedures performed. (National Center for Health Statistics based on Classification of Diseases, 9th Revision, Clinical Modification for the following categories: ICD-9 CM Code: 04.3, 04.5, 04.6, 04.7). These data, however, probably underestimate the number of nerve injuries appreciated, as not all surgical or traumatic lesions can be repaired. Further, intraabodominal procedures may add to the number of neurologic injuries by damage to the autonomic system through tumor resection. For example, studies assessing the outcome of impotency following radical prostatectomy demonstrated 212 of 503 previously potent men (42%) suffered impotency when partial or complete resection of one or both cavernosal nerve(s). This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J.

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Section: Scaffoldmentioning

confidence: 99%

Peripheral nerve injury: A review and approach to tissue engineered constructs

2001

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“…Molander et al (1982) prepared copolymer meshes (0.4 x 0.4 mm for pore size) of polyglycolic acid and polylactic acid to repair a 9-mm gap in tibial nerves of 24 rabbits. The mesh was shaped into a tube which sealed off the defect.…”

Section: Nerve Bridge Technique Used To Repair Short Gapsmentioning

confidence: 99%

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

et al. 1998

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

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“…Studies on large neural tissue losses and the need of bridges connecting proximal and distal ends have been conducted during the second half of Nineteenth Century (4) . Some authors used other materials in replacement of nerve graft, such as vessels (5,6) , fascia (7) , plastic tubes (8) , absorbable tubes, silicone tubes (9) , muscle (10) and synthetic tubes (11) . The use of absorbable tube made of polyglycolic acid has been extensively investigated in literature (12) and no statistically significant differences were observed between this approach and the nerve graft for peripheral nerves repair (13) .…”

Section: Introductionmentioning

confidence: 99%

A utilização do tubo de ácido poliglicólico e FK506 na regeneração de nervos periféricos

et al. 2006

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SUMMARYExtensive losses of neural tissue preclude the repair performed by means of primary anastomosis. In those cases, nerve autograft is considered as the treatment of choice. The synthetic tube constituted by polyglycolic acid is an option for nerve graft. The FK506 is an immunosuppressive agent, which increases the neural regeneration rates in vivo and in vitro. The purpose of this study was to compare, in rats, the degree of neural regeneration, by using histological analysis, a count of the number of regenerated myelinated axons, and a functional analysis, obtained by interposing the autogenous graft (group A), polyglycolic acid tube (group B) and a combination of polyglycolic acid tube with FK506 (group C) in 5-cm defects of the sciatic nerve. Neuroma formation was observed only in group A. Groups B and C presented similar histological patterns. The quantitative analysis of the number of regenerated myelinated axons has determined that: 1) group B presented, in average, a lower number when compared to the other groups; 2) there was no significant difference between control group A and group C. For functional recovery, there was no statistically significant change between the three groups, despite the qualitative and quantitative histological differences seen.

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Regeneration of peripheral nerve through a polyglactin tube

Cited by 191 publications

References 13 publications

Peripheral nerve injury: A review and approach to tissue engineered constructs

Peripheral nerve injury: A review and approach to tissue engineered constructs

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

A utilização do tubo de ácido poliglicólico e FK506 na regeneração de nervos periféricos

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