Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Abstract

Regenerative properties of fibroin implant vitalized with allogeneic bone marrow cells were assessed. The study was performed using the experimental model of rat jejunum wall damage. Three weeks after surgery, we observed recovery of all layers of the jejunum wall at the site of injury and complete degradation of the implant material.

Almost 40 Years of Tissue Engineering in Russia: Where Are We Now?

“…Though skin tissue engineering was the first branch of tissue engineering to develop, soon it took a back seat and scientists all over the world, including Russia, switched to developing cell products for the regeneration of other tissues and organs. In the Russian Federation, scientists then worked on bone [14] and cartilage [15] equivalents and the treatment of defects and dysfunction of different organs such as the urethra [16,17], bladder [18], heart [19], central nervous system [20], liver [21], gut [22], pancreas [23], eye [24], teeth [25], hair follicle [26], etc., using implants made of different polymeric scaffolds populated with living cells (summarized in Table 3). Other techniques like transplantations of the decellularized matrix, cells or scaffolds alone, or scaffolds impregnated with active biological molecules, cells bearing modified genes or bearing gene constructs, or differentiated induced pluripotent stem cells (iPSCs), are also popular in Russia.…”