Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties

Hu, Cheng; Liu, Wenqi; Long, Linyu; Wang, Zhicun; Zhang, Wen; He, Shuyi; Lu, Lu; Fan, Hongsong; Li, Yang; Wang, Yunbing

doi:10.1016/j.biomaterials.2022.121849

Cited by 46 publications

(29 citation statements)

References 52 publications

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“…In addition, the effect of immunomodulation on angiogenesis in vitro under different treatments was investigated by HUVEC cells tube formation assay. [ 38 ] As shown in Figure 4G,I–K, the length of vessel formation, the number of mesh and the number of vessel formation are significantly greater in the FGMA/FG/PA group than in the control group. According to the correlation analysis (Figure 4L), the ability of CM of macrophages to promote the migration and tube‐formation of HUVEC cells is mainly related to the expression of TNF‐ α , TGF‐ β , and VEGF.…”

Section: Resultsmentioning

confidence: 95%

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Shi

Wang

et al. 2023

Advanced Science

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Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro‐inflammatory (M1) macrophages in the wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise in promoting diabetic wound healing in clinical applications. However, the precise conversion of pro‐inflammatory M1 to anti‐inflammatory M2 macrophages by simple and biosafe approaches is still a great challenge. Here, an all‐natural hydrogel with the ability to regulate macrophage heterogeneity is developed to promote angiogenesis and diabetic wound healing. The protocatechuic aldehyde hybridized collagen‐based all‐natural hydrogel exhibits good bioadhesive and antibacterial properties as well as reactive oxygen species scavenging ability. More importantly, the hydrogel is able to convert M1 macrophages into M2 macrophages without the need for any additional ingredients or external intervention. This simple and safe immunomodulatory approach shows great application potential for shortening the inflammatory phase of diabetic wound repair and accelerating wound healing.

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Section: Resultsmentioning

confidence: 95%

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Shi

Wang

et al. 2023

Advanced Science

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“…In this study, the CCK-8 method was used to detect the cytotoxicity of PLCL-GNR/PEG (Figure a). Human umbilical vein endothelial cells (HUVECs) and rat cardiomyocytes (H9C2) were selected as model cell lines because they are the main cells contacted after occluder implantation and responsible for cardiac tissue regeneration . As shown in Figures b, c and S7, both HUVEC and H9C2 cell viabilities of all the PLCL-GNR/PEG samples were similar to that of PLLA and reached 90%, indicating that the composites exhibit satisfactory cytocompatibility.…”

Section: Resultsmentioning

confidence: 96%

Near-Infrared Remotely Controllable Shape Memory Biodegradable Occluder Based on Poly(l-lactide-co-ε-caprolactone)/Gold Nanorod Composite

Xiang,

Zhang,

Zhou

et al. 2023

ACS Appl. Mater. Interfaces

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“…[ 16a ] After activation they release the pro‐inflammatory cytokine mediators including tumor necrosis factor‐alpha (TNF‐ α ) and interleukin‐6 (IL‐6). [ 42 ] It is obvious that, compared to the many macrophages that display a spreading shape on the pristine PU surface, in contrast the oval shaped macrophages in the inactivated state populate the PDA/Lys/Cu‐SB coated PU surface. This indicates a low activation level in the macrophages attached to PDA/Lys/Cu‐SB coated PU substrates.…”

Section: Resultsmentioning

confidence: 99%

Surface Engineering of Central Venous Catheters via Combination of Antibacterial Endothelium‐Mimicking Function and Fibrinolytic Activity for Combating Blood Stream Infection and Thrombosis

Peng

Liu

et al. 2023

Adv Healthcare Materials

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Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration of endothelium‐mimicking and fibrinolytic functions. In this proposal, a lysine (Lys)/Cu2+‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed and robustly fabricated onto commercial CVCs using a facile two‐step process. Initially, adhesive ene‐functionalized dopamine is covalently reacted with Lys and simultaneously coordinated with bactericidal Cu2+ ions, leading to the deposition of a PDA/Lys/Cu coating on CVCs through mussel foot protein inspired surface chemistry. Next, zwitterionic poly(sulfobetaine methacrylate) (pSB) brushes are grafted onto the PDA/Lys/Cu coating to endow lubricant and antifouling properties. In the final PDA/Lys/Cu‐SB coating, endothelium‐mimicking function is achieved by combining the catalytic generation of nitric oxide from the chelated Cu2+ with antifouling pSB brushes, which led to significant prevention of thrombosis, and bacterial infection in vivo. Furthermore, the immobilized Lys with fibrinolytic activity show remarkably enhanced long‐term anti‐thrombogenic properties as evidenced in vivo by demonstrating the capability to lyse nascent clots. Therefore, this developed strategy provides a promising solution for long‐term blood‐contacting devices to combat thrombosis and infection.

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Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties

Cited by 46 publications

References 52 publications

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Near-Infrared Remotely Controllable Shape Memory Biodegradable Occluder Based on Poly(l-lactide-co-ε-caprolactone)/Gold Nanorod Composite

Surface Engineering of Central Venous Catheters via Combination of Antibacterial Endothelium‐Mimicking Function and Fibrinolytic Activity for Combating Blood Stream Infection and Thrombosis

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