Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma

Cotanche, Douglas A.

doi:10.1016/0378-5955(87)90135-3

Cited by 353 publications

(211 citation statements)

References 25 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…As in previous behavioral studies (Okanoya and Dooling, 1985;1987;Okanoya et al, 1990) we found that the threshold difference between Waterslagers and controls is much larger for frequencies above 1 kHz than for lower frequencies. We do not know the frequency distribution along the canary basilar papilla, but from the known tonotopy in other birds (chicken, Manley et al, 1987;starling, Gleich, 1989;barn owl, K6ppl et al, 1993) we know that the high frequencies are represented at the base and low frequencies at more apical locations of the papilla.…”

Section: /Hearing Research 79 (1994) 123-136 133supporting

confidence: 89%

“…Though it has been known for several years that there are strain differences in auditory sensitivity in canaries, it remained unclear whether these elevated thresholds were due to middle ear, cochlear or central nervous anomalities (Okanoya and Dooling, 1985;1987). There were indications, however, that this phenomenon has a genetic basis (Okanoya et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…above 2 kHz) that are 20-40 dB higher than the thresholds from those of other strains of canaries and of other birds (Dooling, 1982;1992;Okanoya and Dooling, 1985;1987). The behavioral evidence suggests that this auditory deficit is inherited, in that thresholds from canaries obtained from crossbreeding a Waterslager and a German Roller canary vary from the completely normal pattern of threshold sensitivity found in German Rollers to the elevated pattern of threshold sensitivity found in Waterslagers, with some offspring showing an intermediate pattern (Okanoya et al, 1990).…”

Section: Introductionmentioning

confidence: 90%

“…There have been a number of studies describing cochlear pathology in birds as a result of acoustic overstimulation (Cotanche, 1987;Cotanche et al, 1987;Cotanche and Corwin, 1991;Cousillas and Rebillard, 1988;Corwin and Cotanche, 1988;Girod et al, 1989;Saunders et al, 1992) and ototoxicity of antibiotic drugs (Hashino et al, 1992;Hashino et al, 1991;Girod et al, 1991;Pickles and Rouse, 1991). We can thus compare the pathologies found in the cochlea of the Waterslagers with those observed in other birds after insult to the cochlea.…”

Section: /Hearing Research 79 (1994) 123-136 133mentioning

confidence: 99%

“…The apparatus for the behavioral audiometry has been described previously (Okanoya and Dooling, 1985;1987;1990a,b). Briefly, a two-key operant panel was constructed using sensitive microswitches and lightemitting/diodes (LEDs).…”

Section: Behauioral Audiogramsmentioning

confidence: 99%

See 4 more Smart Citations

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Gleich

Dooling²,

Manley

1994

Hearing Research

View full text Add to dashboard Cite

Recent reports of elevated auditory thresholds in canaries of the Belgian Waterslager strain have shown thai this strain has an inherited auditory deficit in which absolute auditory thresholds at high frequencies (i.e. above 2.(1 kHz) are as much as 41) dB less sensitive than the thresholds of mixed-breed canaries and those of other strains. The measurement of CAP audiograms showed that the hearing deficit is already present at the level of the auditory nerve (Gleich and Dooling, 1992). Here we show gross abnormalities in the anatomy of the basilar papilla of Belgian Waterslager canaries at the level of the hair cell. The extent of these abnormalities was correlated with the amount of hearing deficit as measured behaviorally.

show abstract

Section: /Hearing Research 79 (1994) 123-136 133supporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: /Hearing Research 79 (1994) 123-136 133mentioning

confidence: 99%

Section: Behauioral Audiogramsmentioning

confidence: 99%

See 3 more Smart Citations

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Gleich

Dooling²,

Manley

1994

Hearing Research

View full text Add to dashboard Cite

show abstract

Distribution of nerve fibers in the basilar papilla of normal and sound-damaged chick cochleae

Ofsie

Cotanche

1996

J. Comp. Neurol.

View full text Add to dashboard Cite

Epifluorescent light microscopy and confocal laser scanning microscopy were employed to visualize the distribution of nerve fibers in whole-mount preparations of normal and sound-damaged chick basilar papillae (BP). In normal cochleae, we identified a consistent pattern of nerve processes that ran transversely across the BP. The transverse processes increase in number from the proximal to the distal ends of the epithelium. However, when the processes are separated into populations of thin fibers and thick bundles, the thin fibers are more prevalent in distal regions whereas thick bundles are more extensive in proximal regions. Furthermore, the thick bundles form an elaborate longitudinal network in the border cell and hyaline cell region. Based on these data and no other previous studies, the thin fibers appear to be afferent nerves and the thick bundles represent efferent nerves. When birds are exposed to acoustic trauma, the normal pattern and number of nerve processes is not altered by levels of sound that produce moderate levels of damage, i.e., damage that leads to hair cell loss and regeneration. However, the nerve pattern is disrupted by severe levels of damage that destroy both hair cells and supporting cells. These findings indicate that the level of sound exposure that induces hair cell regeneration may damage the synaptic endings associated with the lost hair cells, but that the nerve processes that give rise to these endings remain intact within the sensory epithelium. In contrast, severe damage destroys both the hair cells and their associated nerve fibers.

show abstract

Evidence for supporting cell proliferation and hair cell differentiation in the basilar papilla of adult Belgian Waterslager canaries (Serinus canarius)

1997

View full text Add to dashboard Cite

We used the bromodeoxyuridine technique to study the proliferative activity in the basilar papilla of normal and Belgian Waterslager canaries with and without preceding sound trauma. Without sound trauma, there were, on average, six supporting cell divisions per day in the basilar papilla of Waterslager canaries. This rate of supporting cell proliferation corresponds well with estimates of the rate of hair cell differentiation derived from counts of immature-appearing hair cells obtained by using scanning electron microscopy of the Waterslager basilar papilla. Thus, supporting cell division appeared correlated with hair cell differentiation in Waterslager canaries. Bromodeoxyuridine labeling of cells in undamaged non-Waterslager canaries also indicated a very low rate of supporting cell division. In contrast with Waterslager canaries, this low rate of proliferation was not associated with a measurable rate of hair cell differentiation. In both normal and Waterslager canaries, exposure to traumatizing sound induced a dramatic increase in the rate of cell proliferation. These data show that a very low rate of supporting cell proliferation is normally present in birds, but it is not associated with a corresponding rate differentiation of hair cells. Only an increase above this low ambient rate of supporting cell proliferation, such as that following loss of hair cells, induces the differentiation of new hair cells in birds. The reason why Waterslager canaries do not completely compensate for their inherited hair cell deficit of 30% is not clear, when they can clearly respond to additional cochlear trauma from noise exposure with an increase in proliferation rate.

show abstract

Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma

Cited by 353 publications

References 25 publications

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius)

Distribution of nerve fibers in the basilar papilla of normal and sound-damaged chick cochleae

Evidence for supporting cell proliferation and hair cell differentiation in the basilar papilla of adult Belgian Waterslager canaries (Serinus canarius)

Contact Info

Product

Resources

About