Regeneration of degenerated articular cartilage after high tibial valgus osteotomy for medial compartmental osteoarthritis of the knee

Does the Taylor Spatial Frame Accurately Correct Tibial Deformities?

“…Osteotomy of the tibia can reliably correct malalignment and one report suggests it may lead to cartilage regeneration [19]. Achieving overcorrection with a high tibial osteotomy (HTO) is important for achieving long-term success in the treatment of unicompartmental arthrosis [6,42].…”

Nanotechnology and mesenchymal stem cells with chondrocytes in prevention of partial growth plate arrest in pigs

“…In microscopic examination of the specimen stained with hematoxylin and eosin, the coherence of the newly-formed tissue with the surrounding structure of the original growth plate cartilage and the maturity of cartilage in the defect were evaluated. The properties of the newly-created physis were assessed on a scale of 0 to 3 points and modified O'Driscoll score was applied with regard to the renewal of columnar cell formation [5][6][7][8] . Immunohistochemical reaction detected type-II collagen fibers and fibre content in the intracellular matrix of the newly-created tissue in the defect of the growth plate.…”

Disease modification in osteoarthritis: Are drugs the answer?

“…Osteotomy and joint distraction are examples. Clear evidence of improvements in joint space width (JSW) and cartilage repair (although with fibrocartilage rather than hyaline cartilage) has been reported following osteotomies to correct mechanical abnormalities in OA of the hip or knee (19), and the beneficial effects of joint distraction on ankle joint OA appear to be accompanied by widening of the joint space due to cartilage repair (20). Therefore, perhaps other, simpler mechanical interventions, such as shoe wedging (21), will have the same effect.…”