Regeneration of critical injuries of the peripheral nerve with growth factors

Medrano, Belén García; Sanz, Patricia Barrio; Pérez, C. Simón; Andrino, Alejandro León; Garrosa, Manuel; Ferrero, M.A. Martín; Rodríguez, M.J. Gayoso

doi:10.1016/j.recote.2013.03.008

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…(1) to identify the determining aspects of adherence to orthotic treatment in patients with peripheral neuropathy, (2) to establish the relationship between the aspects and adherence to orthotic treatment, and (3) to classify the aspects according to Kano's three-factor theory.…”

Section: Most Studies Use Validated Tools Such As the Orthotics And P...mentioning

confidence: 99%

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Aspects determining adherence to wrist-hand orthoses in patients with peripheral neuropathies

Bula-Oyola

Belda-Lois

Porcar-Seder

et al. 2022

TAD

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BACKGROUND: People with peripheral neuropathies suffer significant sensorimotor impairment. Prescribed treatment includes the use of orthosis. However, a common obstacle to treatment efficacy is patient adherence. Given the limited information available, gathering evidence on adherence to orthotic treatment is essential. OBJECTIVE: This study aims to identify aspects that influence adherence to orthotic treatment in patients with peripheral neuropathies. METHODS: We applied a survey including items from the assistive device evaluation section of Quest 2.0 and self-developed questions to assess the importance and satisfaction of wrist-hand orthosis users. We used the principles of the Kano model to understand the nature of issues influencing adherence and prioritize opportunities for product improvement. RESULTS: User satisfaction with the ease of adjustment, weight, comfort, effectiveness, durability, dimensions, and appearance of orthoses influences treatment adherence. CONCLUSIONS: We found differences in estimating the importance of orthosis aspects from direct consultation and estimation from the satisfaction-adherence correlation. Satisfaction is an indirect measure of importance and an adequate predictor of adherence. The application of Kano’s model allows a more precise identification of the influence of orthosis attributes on adherence. This method describes relationships between aspects that are not discernible in linear models.

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Section: Most Studies Use Validated Tools Such As the Orthotics And P...mentioning

confidence: 99%

“…Traumatic peripheral nerve injuries cause chronic pain and significantly impair sensorimotor functions. In the long term, they can reduce patients' quality of life who acquire permanent secondary disability [1,2].…”

Section: Introductionmentioning

confidence: 99%

Aspects determining adherence to wrist-hand orthoses in patients with peripheral neuropathies

Bula-Oyola

Belda-Lois

Porcar-Seder

et al. 2022

TAD

View full text Add to dashboard Cite

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Rapamycin promotes Schwann cell migration and nerve growth factor secretion

Liu

Zhang

et al. 2014

Neural Regen Res

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Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Schwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration (100μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.

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Regeneration of critical injuries of the peripheral nerve with growth factors

Cited by 2 publications

References 23 publications

Aspects determining adherence to wrist-hand orthoses in patients with peripheral neuropathies

Aspects determining adherence to wrist-hand orthoses in patients with peripheral neuropathies

Rapamycin promotes Schwann cell migration and nerve growth factor secretion

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