Regeneration of bone marrow after tibial ablation in immunocompromised rats is age dependent

Fisher, Maya; Hyzy, Sharon L.; Guldberg, Robert E.; Schwartz, Zvi; Boyan, Barbara D.

doi:10.1016/j.bone.2009.09.029

Cited by 10 publications

(15 citation statements)

References 25 publications

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“…Our findings of a significantly greater percentage of new bone formation in younger patients relative to older ones following remodeling with cancellous block-allograft in the anterior atrophic maxilla and posterior atrophic mandible (Nissan et al, 2011d;Nissan et al, 2011e) agree with earlier studies of the effect of age on new bone formation (Fisher et al, 2010;Matsumoto et al, 2001;Rando, 2006;Tanuka et al, 1996;Walboomers et al, 2006). Following induction of injury to the tibia marrow cavity in a rat model, MicroCT and histomorphometry revealed a reduced response with an increase in age, suggesting that the restoration of normal tissue is age-dependent (Fisher et al, 2010).…”

Section: Commentsupporting

confidence: 91%

“…Following induction of injury to the tibia marrow cavity in a rat model, MicroCT and histomorphometry revealed a reduced response with an increase in age, suggesting that the restoration of normal tissue is age-dependent (Fisher et al, 2010). Others also noted differences in the osteogenic properties of bone marrow-derived osteoblast-like cells by donor age (Walboomers et al, 2006).…”

Section: Commentmentioning

confidence: 99%

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The Use of Cancellous Bone-Block Allograft for Reconstruction of the Atrophic Alveolar Ridge

Chaushu¹,

Nissan²

2012

Bone Regeneration

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Section: Commentsupporting

confidence: 91%

Section: Commentmentioning

confidence: 99%

The Use of Cancellous Bone-Block Allograft for Reconstruction of the Atrophic Alveolar Ridge

Chaushu¹,

Nissan²

2012

Bone Regeneration

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“…The tibial marrow ablation model is an established model to study endosteal bone formation followed by bone marrow regeneration in mammals, such as rats, rabbits and guinea pigs [17,[20][21][22][23]. In this study, the choice for the medullary cavity of guinea pigs for material injection was based on three preliminary facts: (1) two small holes are sufficient as an easily accessible site for injection; (2) the procedure ensures complete filling of the cavity using injectable materials, i.e.…”

Section: Animal Model and Surgical Proceduresmentioning

confidence: 99%

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

et al. 2013

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Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs, Acta Biomaterialia (2012), doi: http://dx.doi.org/10. 1016/j.actbio.2012.10.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Several studies have reported conflicting results on whether the healing capacity diminishes with increasing age (21,22). Endosteal bone formation and marrow regeneration following tibial marrow ablation are delayed with increasing age in immunocompromised rats (22). Healing of segmental fracture defects was delayed in older animals with demineralized bone matrix (DBM) treatment compared to younger animals (21).…”

Section: Discussionmentioning

confidence: 99%

“…Another factor that is known to play a role in bone formation is age. Several studies have shown that both natural bone formation and bone fracture healing in response to osteoinductive factors is impaired in an aged population (21,22). The results of these studies suggest that new bone formation surrounding Ti implants may also be affected by patient age.…”

Section: Introductionmentioning

confidence: 99%

Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

Olivares-Navarrete

Raines

Hyzy

et al. 2012

Journal of Bone and Mineral Research

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The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. While the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1-, 3-, and 11-month-old rats all displayed a reduction in cell number and increases in alkaline phosphatase specific activity and osteocalcin in response to increasing Ti surface microtopography and surface energy. Further, osteoblasts from the three ages examined displayed increased production of osteocalcin and local factors osteoprotegerin, VEGF-A, and active TGF-β1 in response to increasing Ti surface roughness and surface energy. Latent TGF-β1 only increased in cultures of osteoblasts from 1- and 3-month-old rats. Treatment with the systemic osteotropic hormone 1α,25(OH)2D3 further enhanced the response of osteoblasts to Ti surface features for all three age groups. However, osteoblasts derived from 11-month-old animals had a reduced response to 1α,25(OH)2D3 as compared to osteoblasts derived from 1-or 3-month-old animals. These results were confirmed in vivo. Ti implants placed in the femoral intramedullary canal of old (9-month) mice yielded lower bone-to-implant contract and neovascularization in response to Ti surface roughness and energy compared to younger (2-month) mice. These results show that rodent osteoblast maturation in vitro as well as new bone formation in vivo is reduced with age. Whether comparable age differences exist in humans needs to be determined.

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Regeneration of bone marrow after tibial ablation in immunocompromised rats is age dependent

Cited by 10 publications

References 25 publications

The Use of Cancellous Bone-Block Allograft for Reconstruction of the Atrophic Alveolar Ridge

The Use of Cancellous Bone-Block Allograft for Reconstruction of the Atrophic Alveolar Ridge

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

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