Regeneration neurohormones and growth factors in echinoderms

Thorndyke, Michael C.; Carnevali, M. Daniela Candia

doi:10.1139/cjz-79-7-1171

Cited by 19 publications

(18 citation statements)

References 132 publications

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“…Both processes are key phenomena in echinoderm biology and are plausibly regulated by humoral mechanisms (Watts et al 1994; Thorndyke and Candia Carnevali 2001;Candia Carnevali 2005). On the basis of the species-specific characteristics and capacities, the possible effects on reproductive biology were analyzed in both crinoids and echinoids, whereas the regenerative response was explored only in crinoids.…”

Section: Echinoderms As Test Species For Endocrine Disruption Assessmmentioning

confidence: 98%

Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem

et al. 2007

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Echinoderms are valuable test species in marine ecotoxicology and offer a wide range of biological processes appropriate for this approach. In spite of this potential, available data in literature are still rather limited, particularly with regard to the possible effects of endocrine disrupter compounds (EDCs). This review presents echinoderms as useful models for ecotoxicological tests and gives a brief overview of the most significant results obtained in recent years, particularly in the context of the COMPRENDO EU project. In this research project two different aspects of echinoderm physiology, plausibly regulated by humoral mechanisms, were investigated: reproductive biology and regenerative development. Selected EDCs suspected for their androgenic or antiandrogenic action were tested at low concentrations. The results obtained so far showed that different parameters such as regenerative growth, histological pattern, egg diameter and gonad maturation were affected by the exposure to the selected compounds. These results substantiate that reproductive and regenerative phenomena of echinoderms can be considered valuable alternative models for studies on EDCs and confirm that these compounds interfere with fundamental physiological processes, including growth, development and reproductive competence.

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Section: Echinoderms As Test Species For Endocrine Disruption Assessmmentioning

confidence: 98%

Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem

et al. 2007

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“…The formation of a regeneration blastema is a response to amputation involving mainly cell proliferation, and describes the accumulation of undifferentiated or dedifferentiating cells at the wound site, often visible as an unpigmented bulge in an otherwise pigmented animal. Blastemas have not only been described in various flatworms [ 4 ], but also in annelids [ 5 ], molluscs [ 6 ], nemerteans [ 7 ], echinoderms [ 8 ], crustaceans [ 9 ], teleost fish [ 10 ], urodele amphibians [ 11 ], larval anuran amphibians [ 12 ], lizards [ 13 ] and some mammalians [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The caudal regeneration blastema is an accumulation of rapidly proliferating stem cells in the flatworm Macrostomum lignano

et al. 2009

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Background: Macrostomum lignano is a small free-living flatworm capable of regenerating all body parts posterior of the pharynx and anterior to the brain. We quantified the cellular composition of the caudal-most body region, the tail plate, and investigated regeneration of the tail plate in vivo and in semithin sections labeled with bromodeoxyuridine, a marker for stem cells (neoblasts) in Sphase.

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“…These granules are absorbed by all types of cells involved in regeneration. The contents of the granules may include nutrients and/or factors that cause activation of certain gene cascades [ 37 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Regeneration of the digestive system in the crinoid Himerometra robustipinna occurs by transdifferentiation of neurosecretory-like cells

et al. 2017

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The structure and regeneration of the digestive system in the crinoid Himerometra robustipinna (Carpenter, 1881) were studied. The gut comprises a spiral tube forming radial lateral processes, which gives it a five-lobed shape. The digestive tube consists of three segments: esophagus, intestine, and rectum. The epithelia of these segments have different cell compositions. Regeneration of the gut after autotomy of the visceral mass progresses very rapidly. Within 6 h after autotomy, an aggregation consisting of amoebocytes, coelomic epithelial cells and juxtaligamental cells (neurosecretory neurons) forms on the inner surface of the skeletal calyx. At 12 h post-autotomy, transdifferentiation of the juxtaligamental cells starts. At 24 h post-autotomy these cells undergo a mesenchymal-epithelial-like transition, resulting in the formation of the luminal epithelium of the gut. Specialization of the intestinal epithelial cells begins on day 2 post-autotomy. At this stage animals acquire the mouth and anal opening. On day 4 post-autotomy the height of both the enterocytes and the visceral mass gradually increases. Proliferation does not play any noticeable role in gut regeneration. The immersion of animals in a 10−7 M solution of colchicine neither stopped formation of the lost structures nor caused accumulation of mitoses in tissues. Weakly EdU-labeled nuclei were observed in the gut only on day 2 post-autotomy and were not detected at later regeneration stages. Single mitotically dividing cells were recorded during the same period. It is concluded that juxtaligamental cells play a major role in gut regeneration in H. robustipinna. The main mechanisms of morphogenesis are cell migration and transdifferentiation.

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Regeneration neurohormones and growth factors in echinoderms

Abstract: There has been much recent interest in the presence and biological functions of growth regulators in invertebrates.

Cited by 19 publications

References 132 publications

Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem

Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem

The caudal regeneration blastema is an accumulation of rapidly proliferating stem cells in the flatworm Macrostomum lignano

Regeneration of the digestive system in the crinoid Himerometra robustipinna occurs by transdifferentiation of neurosecretory-like cells

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