Regeneration, neural crest derivatives and retinoids: A new synthesis

Baranowitz, Steven

doi:10.1016/s0022-5193(89)80131-6

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Evidence is also presented regarding the role of retinoic acid in neural crest induction. The latter is a novel finding, as this molecule has previously only been proposed to participate in neural crest differentiation (Baranowitz, 1989;Dupe et al, 1999). It has also been shown that treatment of Xenopus embryos with retinoic acid affects the development of cranial nerves derived from neural crest (Papalopulu et al, 1991).…”

Section: Molecules Involved In Neural Crest Inductionmentioning

confidence: 87%

Posteriorization by FGF, Wnt, and Retinoic Acid Is Required for Neural Crest Induction

Villanueva

Glavic

Ruíz

et al. 2002

Developmental Biology

218

223

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The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain. Here, the roles of BMPs, FGFs, Wnts, and retinoic acid signaling in neural crest induction were analyzed by using an assay developed for investigating the posteriorization of the neural plate. Using specific markers for the anterior neural plate border and the neural crest, the posterior end of early neurula embryos was shown to be able to transform the anterior neural plate border into neural crest cells. In addition, tissue expressing anterior neural plate markers, induced by an intermediate level of BMP activity, was transformed into neural crest by posteriorizing signals. This transformation was mimicked by bFGF, Wnt-8, or retinoic acid treatment and was also inhibited by expression of the dominant negative forms of the FGF receptor, the retinoic acid receptor, and Wnt signaling molecules. The transformation of the anterior neural plate border into neural crest cells was also achieved in whole embryos, by retinoic acid treatment or by use of a constitutively active form of the retinoic acid receptor. By analyzing the expression of mesodermal markers and various graft experiments, the expression of the mutant retinoic acid receptor was shown to directly affect the ectoderm. We thereby propose a two-step model for neural crest induction. Initially, BMP levels intermediate to those required for neural plate and epidermal specification induce neural folds with an anterior character along the entire neural plate border. Subsequently, the most posterior region of this anterior neural plate border is transformed into the neural crest by the posteriorizing activity of FGFs, Wnts, and retinoic acid signals. We discuss a unifying model where lateralizing and posteriorizing signals are presented as two stages of the same inductive process required for neural crest induction.

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Section: Molecules Involved In Neural Crest Inductionmentioning

confidence: 87%

Posteriorization by FGF, Wnt, and Retinoic Acid Is Required for Neural Crest Induction

Villanueva

Glavic

Ruíz

et al. 2002

Developmental Biology

218

223

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Avian Aesthetics

Brush¹

1991

Arch Dermatol

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Progress in clinical dermatology is derived from new diagnostic and therapeutic approaches and requires increased understanding of the cellular and macromolecular basis of physiology and pathophysiology. Researchers are excited and animated by their experiments and data, yet the research literature frequently fails to convey this immediacy. Why? In part, the convention and form of scientific journals and the eschewing of speculation make the literature inaccessible to the nonscientist. This section of the ARCHIVES will select broadly from the research literature relevant to dermatology and will attempt to integrate what is new in the research laboratory with the physicians' knowledge. Readers' comments are solicited.

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Identification and functional characterization of CD133+GFAP+CD117+Sca1+ neural stem cells

Yang

Zhu

et al. 2022

Mol Cell Biochem

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Regeneration, neural crest derivatives and retinoids: A new synthesis

Cited by 5 publications

References 41 publications

Posteriorization by FGF, Wnt, and Retinoic Acid Is Required for Neural Crest Induction

Posteriorization by FGF, Wnt, and Retinoic Acid Is Required for Neural Crest Induction

Avian Aesthetics

Identification and functional characterization of CD133+GFAP+CD117+Sca1+ neural stem cells

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