Regeneration: From cells to tissues to organisms

Echeverri, Karen; Zayas, Ricardo M.

doi:10.1016/j.ydbio.2017.12.005

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Regeneration and development are famously intertwined and the relationship between the two processes has been investigated for more than a century [ 99 ]. Many studies and reviews in the fields of both embryonic developmental biology and regeneration biology have contemplated the extent to which regeneration is a recapitulation of development, with the general consensus that it is likely driven by the same gene networks, but the specific pathways deployed may be regeneration-specific [ 15 , 48 , 134 ]. In part, this question has been difficult to answer due to a lack of large-scale comparative analyses with genomic datasets that sample comprehensively across both developmental and regenerative time courses.…”

Section: Ecological Evolutionary and Genomic Context Of Sea Anemone Regenerationmentioning

confidence: 99%

The Tentacular Spectacular: Evolution of Regeneration in Sea Anemones

Burg

Prentis

2021

Genes

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Sea anemones vary immensely in life history strategies, environmental niches and their ability to regenerate. While the sea anemone Nematostella vectensis is the starlet of many key regeneration studies, recent work is emerging on the diverse regeneration strategies employed by other sea anemones. This manuscript will explore current molecular mechanisms of regeneration employed by non-model sea anemones Exaiptasia diaphana (an emerging model species for coral symbiosis studies) and Calliactis polypus (a less well-studied species) and examine how these species compare to the model sea anemone N. vectensis. We summarize the field of regeneration within sea anemones, within the greater context of phylum Cnidaria and in other invertebrate models of regeneration. We also address the current knowledge on two key systems that may be implemented in regeneration: the innate immune system and developmental pathways, including future aspects of work and current limitations.

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