Regeneration after tall hair cell damage following severe acoustic trauma in adult pigeons: correlation between cochlear morphology, compound action potential responses and single fiber properties in single animals

Müller, Marcus; Smolders, Jean W.T.; Ding‐Pfennigdorff, Danping; Klinke, Rainer

doi:10.1016/s0378-5955(96)00155-4

Cited by 18 publications

(22 citation statements)

References 54 publications

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“…This observation suggests that a full complement of hair cells is not necessary for relatively normal hearing in the goldfish. Similar results have been seen in birds, and several authors have suggested that the early phase of recovery may depend more on regeneration of the tectorial membrane or restoration of micromechanical properties than on hair cell regeneration (McFadden and Saunders, 1989;Saunders et al, 1992;Adler et al, 1993;Niemiec et al, 1994;Müller et al, 1996). Although fishes do not have a tectorial membrane, they do have an analogous otolithic membrane that couples the hair bundles to the overlying otolith (Popper, 1977).…”

Section: Discussionsupporting

confidence: 67%

Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure

Smith

Coffin

Miller

et al. 2006

Journal of Experimental Biology

129

128

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Many vertebrates, including fishes and marine mammals, rely on acoustic signals for communication. In aquatic environments, where sound propagates five times faster than in air, acoustic signals are particularly important for communication over long distances or in low-light environments. Research on a variety of fishes, however, demonstrates sensitive hearing capabilities even in nonvocalizing fishes, leading to the hypothesis that hearing in fishes evolved for analysis of the complete auditory scene, including both biotic (e.g.

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Section: Discussionsupporting

confidence: 67%

Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure

Smith

Coffin

Miller

et al. 2006

Journal of Experimental Biology

129

128

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“…However, studies of other bird species have shown that the pattern and location of damage can be quite different from that of the chicken [Ryals et al, 1999;Ryals and Dooling, 1996;Ding-Pfennigdorff et al, 1998;Müller et al, 1996]. It is unclear if these differences in the damage patterns are due to differences in the stimuli used, variations in the structure of the cochlea between species or to differences in sound transmission down the basilar membranes of the particular species.…”

Section: Sound Overexposurementioning

confidence: 99%

“…Studies from a number of laboratories have shown that while the general location of damage that results from a particular stimulus is fairly consistent, there can be a broad variability between animals in the severity and extent of hair cell loss within the damaged area [Cotanche et al, 1987Müller et al, 1996;Ding-Pfennigdorff et al, 1998]. In studies of 10-to 14-day-old chick hatchlings it was found that damage does not appear in the basilar papilla until pure-tone intensities exceed 110 dB SPL for periods of 24-48 h. At the upper limit, pure-tone intensities approaching 125 dB SPL for periods of 24-48 h can cause a complete destruction of both the hair cells and supporting cells in the damaged area of the basilar papilla.…”

Section: Effects Of Stimulus Intensity On the Extent Of Damagementioning

confidence: 99%

“…In these cases the sensory epithelium is replaced by a simple squamous epithelial layer derived from the adjacent hyaline cells [Girod et al, 1989;Cotanche et al, 1995]. In comparison, studies of sound damage in the pigeon utilized pure tones at intensities of greater than 140 dB SPL for only 1 h to produce broad areas of hair cell damage [Müller et al, 1996;Ding-Pfennigdorff et al, 1998]. …”

Section: Effects Of Stimulus Intensity On the Extent Of Damagementioning

confidence: 99%

“…The occurrence of both moderate and severe damage in the pigeon and their impact on functional recovery has been documented in great detail [Müller et al, 1996;Ding-Pfennigdorff et al, 1998; see also the accompanying review by Smolders, 1999]. In these studies the functional recovery was directly compared to the level of damage and regeneration in each pigeon for a large number of birds exposed to similar stimuli.…”

Section: Effects Of Stimulus Intensity On the Extent Of Damagementioning

confidence: 99%

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Structural Recovery from Sound and Aminoglycoside Damage in the Avian Cochlea

Cotanche

1999

Audiol Neurotol

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Hair cell regeneration in the mature avian cochlea occurs in response to trauma that causes the death of some or all of the existing hair cell population. In general, this trauma has been introduced experimentally by either sound overexposure or treatment of the bird with high doses of aminoglycoside antibiotics. When injured hair cells are ejected from the sensory epithelium, the nonsensory supporting cells respond by re-entering the cell cycle and proliferating or by transdifferentiating directly into hair cells without a mitotic event. The new hair cells mature in a manner similar to that seen during embryonic development. They make connections with the overlying tectorial membrane and the afferent and efferent cochlear nerve processes within the sensory epithelium. This structural regeneration is accompanied by a significant recovery of auditory function and thus allows the animal to regain its hearing ability. This hair cell regeneration is presumably quite beneficial to birds, whose primary means of communication is based on vocalizations and the ability to hear and comprehend them. The prevalence of hearing loss in our society and the isolating impact it has on affected individuals makes the potential for finding ways to induce a similar hair cell regeneration in humans a very tempting goal. Studies of hair cell regeneration over the last 12 years have focused on the mechanisms that regulate the process and how they could be controlled. This review will examine the structural events involved in regenerating hair cells in the avian cochlea after sound damage and aminoglycoside treatment. It will define how hair cells and nerve endings are lost and the tectorial membrane is damaged by the traumatizing stimuli and how the supporting cells and nerve fibers respond by producing new hair cells, a new tectorial membrane and new synaptic connections during recovery. Finally, it will focus on mechanisms that control the proliferation and transdifferentiation of supporting cells and the differentiation of new hair cells. This structural review is accompanied by a companion review that covers the fundamental issues concerning functional recovery in the avian cochlea associated with hair cell regeneration.

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Overview: Regeneration and Repair

Salvi¹

Hair Cell Regeneration, Repair, and Protection

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Regeneration after tall hair cell damage following severe acoustic trauma in adult pigeons: correlation between cochlear morphology, compound action potential responses and single fiber properties in single animals

Cited by 18 publications

References 54 publications

Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure

Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure

Structural Recovery from Sound and Aminoglycoside Damage in the Avian Cochlea

Overview: Regeneration and Repair

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