Regenerating Human Nasal Mucosa Cells Express Peptide Growth Factors

Hormonal changes causing rhinitis in pregnancy among Malaysian women

“…Insulin-like growth factor 1 has been linked to the regenerative activity of the nasal mucosa and also to the formation of nasal polyps. Hansson et al have shown that the presence of peptide growth factors within the human nasal mucosa could correlate with its maintenance and repair 7 . In their study, immunohistochemical investigation of biopsy specimens of healthy human nasal mucosa (from subjects aged 6 to 72 years) showed that intense concentrations of insulin-like growth factor 1 were demonstrable in areas with deficient epithelial lining and inflammatory cells.…”

“…7 In their study, immunohistochemical investigation of biopsy specimens of healthy human nasal mucosa (from subjects aged 6 to 72 years) showed that intense concentrations of insulin-like growth factor 1 were demonstrable in areas with deficient epithelial lining and inflammatory cells. Levels of this latter hormone are also known to rise during the course of pregnancy.…”

“…A direct effect of insulin-like growth factor 1 has been demonstrated in the causation of nasal polyps 7 , 17 . However, nasal examination of our patients with pregnancy rhinitis revealed no nasal polyp formation.…”

Pathological Features of Free Graft and Pedicled Flap in the Nasal Cavity: An Animal Study

“…The ciliary cells and goblet cells, of the paranasal sinus mucosal epithelium, perform an important biological defense role in the upper respiratory tract, by removing foreign bodies with ciliary movement and by the bactericidal effect of the mucus secreted by the goblet cells. Preserving nasal physiological function is important for the prevention of complications such as bacterial engraftment and infection 11,12,26,35,36 …”

“…Preserving nasal physiological function is important for the prevention of complications such as bacterial engraftment and infection. 11,12,26,35,36 In this study, inflammatory cell infiltration of the nasal septal cartilage at the reconstruction site was also examined. The ischemic and surrounding tissues promotes inflammatory cell infiltration due to the effect of secreted cytokines.…”