Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure

Jing, Yanting; Ruan, Li-Ming; Jiang, Guohua; Shavandi, Amin; Sun, Yanfang; Xu, Jun; Shao, Xin; Zhu, Junlan

doi:10.1016/j.bioadv.2023.213405

Cited by 19 publications

(9 citation statements)

References 65 publications

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“…Hu H et al [14] prepared a biocomposite hemostatic membrane with calcium/flavopiridol double crosslinked alginate/chitosan/collagen, which has good biocompatibility and biodegradability, and can be used to inhibit bacteria for a long period of time and promote wound healing. Chronic diabetic foot ulcer is a devastating complication of diabetes mellitus, which affects the morbidity, mortality and quality of life of patients.Theocharidis G et al [15] prepared alginate bandages with micrometer pore size and loaded with M2 macrophages through lyophilization, calcium cross-linking, and secondary lyophilization steps, and showed that the dressings could be used as a delivery platform for topical treatment of diabetic wounds.Jing Y et al [16] loaded antimicrobial curcumin nanoparticles onto a composite hydrogel of filipin protein and sodium alginate as a dressing for bacterial infection wound healing. The results showed that the porous three-dimensional (three-dimensiongal, 3D) structure of the composite hydrogel dressing facilitated the absorption of exudate from the wound site and promoted the incorporation of cellular nutrients and metabolites, and that the hydrogel improved cell proliferation, anti-inflammation, and benefited vascular remodeling and collagen deposition at the wound site, which significantly improved closure of bacterial infected wounds.…”

Section: Alginatementioning

confidence: 99%

Current Status of Wound Dressing Research in Biomaterials

Yang

2024

IJNRES

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Skin is the body's first defense against external injuries, in daily production life, skin as an organ is easily injured, forming surface trauma. Wound dressings play a pivotal role in the process of skin wound repair. In order to meet the clinical demand for wound dressings, functional wound dressings with excellent biocompatibility, excellent antimicrobial activity, absorption of wound exudate and promotion of wound tissue repair have been developed. We categorize wound dressings into traditional medical dressings and novel medical wound dressings, and review the wound dressings included in the latter in terms of types, preparation methods, and effects. In future treatments for chronic wounds, researchers will integrate and utilize the antimicrobial activity, biocompatibility, and mechanical properties of wound dressings to investigate advanced wound dressings with multiple functions.

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Section: Alginatementioning

confidence: 99%

Current Status of Wound Dressing Research in Biomaterials

Yang

2024

IJNRES

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“…Skin is the biggest organ of the human body, primarily acting as a physical barrier capable of protecting the organism from the external noxa and maintaining proper internal body conditions. Because of its collocation and vulnerable nature, skin is particularly susceptible to traumas or pathological conditions (i.e., burns, mechanical injuries, tumors, or surgeries) that can hinder physiological would healing, a multi-stage process that includes hemostasis, inflammation, and ECM remodeling [191][192][193][194]. Currently, in order to overcome the limitations of autologous grafting, artificial dermis such as Matriderm ® , Terudermis ® , Integra ® , and Dermagraft ® are commonly used.…”

Section: Skin Tissue Regenerationmentioning

confidence: 99%

Silk Fibroin Materials: Biomedical Applications and Perspectives

De Giorgio,

Matera,

Vurro

et al. 2024

Bioengineering

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The golden rule in tissue engineering is the creation of a synthetic device that simulates the native tissue, thus leading to the proper restoration of its anatomical and functional integrity, avoiding the limitations related to approaches based on autografts and allografts. The emergence of synthetic biocompatible materials has led to the production of innovative scaffolds that, if combined with cells and/or bioactive molecules, can improve tissue regeneration. In the last decade, silk fibroin (SF) has gained attention as a promising biomaterial in regenerative medicine due to its enhanced bio/cytocompatibility, chemical stability, and mechanical properties. Moreover, the possibility to produce advanced medical tools such as films, fibers, hydrogels, 3D porous scaffolds, non-woven scaffolds, particles or composite materials from a raw aqueous solution emphasizes the versatility of SF. Such devices are capable of meeting the most diverse tissue needs; hence, they represent an innovative clinical solution for the treatment of bone/cartilage, the cardiovascular system, neural, skin, and pancreatic tissue regeneration, as well as for many other biomedical applications. The present narrative review encompasses topics such as (i) the most interesting features of SF-based biomaterials, bare SF’s biological nature and structural features, and comprehending the related chemo-physical properties and techniques used to produce the desired formulations of SF; (ii) the different applications of SF-based biomaterials and their related composite structures, discussing their biocompatibility and effectiveness in the medical field. Particularly, applications in regenerative medicine are also analyzed herein to highlight the different therapeutic strategies applied to various body sectors.

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“…Emphasizing on the need of antibiotic-free strategies, a research group fabricated implant hydrogel coating using cationic quaternary ammonium salt and GelMA, which exhibited excellent mechanical properties, good cytocompatibility, and good antibacterial activity against a variety of bacteria . Curcumin-loaded sodium alginate and silk fibroin hydrogel dressing was fabricated for bacteria-infected wound treatment, which showed excellent antibacterial activity along with good biocompatibility and tissue adhesive strength . Cerium oxide loaded in a GelMA-based wound-healing patch was fabricated for diabetic wound healing .…”

Section: Introductionmentioning

confidence: 99%

“…14 Curcumin-loaded sodium alginate and silk fibroin hydrogel dressing was fabricated for bacteria-infected wound treatment, which showed excellent antibacterial activity along with good biocompatibility and tissue adhesive strength. 15 Cerium oxide loaded in a GelMA-based wound-healing patch was fabricated for diabetic wound healing. 16 Silver nanoparticles were also fabricated using green synthesis and loaded in bacterial cellulose hydrogel for the treatment of bacteria-infected wounds.…”

Section: Introductionmentioning

confidence: 99%

Gallium Oxide Nanoparticle-Loaded, Quaternized Chitosan-Oxidized Sodium Alginate Hydrogels for Treatment of Bacteria-Infected Wounds

Negi,

Singh

2023

ACS Appl. Nano Mater.

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Delayed wound healing usually involves bacterial infection and hemorrhage. Antibiotic resistance and biofilm formation caused by the overuse and misuse of antibiotics further worsen the problem. Nanoparticle hydrogel systems aimed at controlling hemorrhage and bacterial infection, without the chances of developing resistance, have recently generated significant research interest as efficient wound dressings. In this work, we have developed a multifunctional, β-Ga 2 O 3 nanoparticle-loaded quaternized chitosan-oxidized sodium alginate hydrogels for antibacterial, antibiofilm, and hemostatic applications. The hydrogels demonstrated enhanced reactive oxygen species scavenging activity of >85%, broad-spectrum antibacterial ability of around 90% against both Staphylococcus aureus and Escherichia coli, antibiofilm activity, and hemostatic potential by taking advantage of intrinsic hemostatic, antioxidative, and antibacterial properties of quaternized chitosan along with the antibacterial and antibiofilm properties of gallium nanoparticles. The scratch assay performed on L929 cells showed the complete closure of scratch in 24 h, emphasizing its potential as a drug-free, multifunctional material in wound dressings. As per our knowledge, this is for the first time that the effect of β-Ga 2 O 3 nanoparticle-loaded quaternized chitosan-oxidized sodium alginate hydrogels has been investigated as a treatment strategy for bacteria-infected wounds.

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Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure

Cited by 19 publications

References 65 publications

Current Status of Wound Dressing Research in Biomaterials

Current Status of Wound Dressing Research in Biomaterials

Silk Fibroin Materials: Biomedical Applications and Perspectives

Gallium Oxide Nanoparticle-Loaded, Quaternized Chitosan-Oxidized Sodium Alginate Hydrogels for Treatment of Bacteria-Infected Wounds

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