Regenerated cellulose nanofiber reinforced chitosan hydrogel scaffolds for bone tissue engineering

Maharjan, Bikendra; Park, Jeesoo; Kaliannagounder, Vignesh Krishnamoorthi; Awasthi, Ganesh Prasad; Joshi, Mahesh Kumar; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.carbpol.2020.117023

Cited by 165 publications

(65 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incubation of scaffolds in SBF is a widely accepted strategy for evaluating the biomineralization properties of scaffolds in vitro and determining the feasibility for promoting bone regeneration. [ 17 ] Biomineralization can be characterized by the deposition of bone‐like apatite. Therefore, Alizarin Red S (ARS) staining and SEM observation are usually used to qualitatively and quantitatively evaluate this performance.…”

Section: Resultsmentioning

confidence: 99%

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Liu

Shang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

An ideal periosteum substitute should be able to mimic the periosteum microenvironment that continuously provides growth factors, recruits osteoblasts, and subsequent extracellular matrix (ECM) mineralization to accelerate bone regeneration. Here, a calcium‐binding peptide‐loaded poly(ε‐caprolactone) (PCL) electrospun membrane modified by the shish‐kebab structure that can mimic the periosteum microenvironment was developed as a bionic periosteum. The calcium‐binding peptide formed by the negatively charged heptaglutamate domain (E7) in the E7‐BMP‐2 with calcium ion in the tricalcium phosphate sol (TCP sol) through electrostatic chelation not only extended the release cycle of E7‐BMP‐2 but also promoted the biomineralization of the bionic periosteum. Cell experiments showed that the bionic periosteum could significantly improve the osteogenic differentiation of the rat‐bone marrow‐derived mesenchymal stem cells (rBMSCs) through both chemical composition and physical structure. The in vivo evaluation of the bionic periosteum confirmed the inherent osteogenesis of this periosteum microenvironment, which could promote the regeneration of vascularized bone tissue. Therefore, the hierarchical nanostructured electrospun membrane with periosteum‐mimic microenvironment is a promising periosteum substitute for the treatment of bone defects.

show abstract

Section: Resultsmentioning

confidence: 99%

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Liu

Shang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…They significantly increased mechanical properties of the injectable hydrogel, provided fibrous structure mimicking collagen fiber network, which is natively present in ECM, and ensured more anchorage site for the mouse calvaria pre-osteoblasts (MC3T3-E1). The incorporation of rCLs to the chitosan not only 1.5-fold increased the Young's Modulus of chitosan and provided increased nucleation sites for hydroxyapatite, but also CCK-8 assay and confocal laser scanning microscopy (CLSM) imaging showed increased viability, attachment and proliferation of MC3T3-E1 cells [182].…”

Section: Hydrogels and Electrospun Nanofibersmentioning

confidence: 99%

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

2021

View full text Add to dashboard Cite

Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives.

show abstract

“…Generally, hydrogel is a three-dimensional cross-linked polymeric network and able to absorb and retain a large volume of water due to extensive hydrophilic chains of the polymers employed such as –OH, -NH 2, -COOH, and –SO 3 H that is associated with the polymeric backbones [ 52 , 53 , 54 ]. Physical cross-linking is formed via various mechanisms include ionic interaction, hydrophobic interaction, hydrogen bonding, ultrasonic induction, and crystallization or classified as non-covalent interactions [ 55 , 56 , 57 ].…”

Section: Regenerated Cellulose Productsmentioning

confidence: 99%

Regenerated Cellulose Products for Agricultural and Their Potential: A Review

et al. 2021

View full text Add to dashboard Cite

Cellulose is one of the most abundant natural polymers with excellent biocompatibility, non-toxicity, flexibility, and renewable source. Regenerated cellulose (RC) products result from the dissolution-regeneration process risen from solvent and anti-solvent reagents, respectively. The regeneration process changes the cellulose chain conformation from cellulose I to cellulose II, leads the structure to have more amorphous regions with improved crystallinity, and inclines towards extensive modification on the RC products such as hydrogel, aerogel, cryogel, xerogel, fibers, membrane, and thin film. Recently, RC products are accentuated to be used in the agriculture field to develop future sustainable agriculture as alternatives to conventional agriculture systems. However, different solvent types and production techniques have great influences on the end properties of RC products. Besides, the fabrication of RC products from solely RC lacks excellent mechanical characteristics. Thus, the flexibility of RC has allowed it to be homogenously blended with other materials to enhance the final products’ properties. This review will summarize the properties and preparation of potential RC-based products that reflect its application to replace soil the plantation medium, govern the release of the fertilizer, provide protection on crops and act as biosensors.

show abstract

Regenerated cellulose nanofiber reinforced chitosan hydrogel scaffolds for bone tissue engineering

Cited by 165 publications

References 68 publications

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

Regenerated Cellulose Products for Agricultural and Their Potential: A Review

Contact Info

Product

Resources

About