Regeneração de defeito ósseo crítico após implantação de fosfato de cálcio bifásico (β-fosfato tricálcico/pirofosfato de cálcio) e vidro bioativo fosfatado

Almeida, Roseane Soares; Silva, Marcelo Henrique Prado da; Rocha, Daniel Navarro da; Ribeiro, I. I. A.; Júnior, A. A. Barbosa; Miguel, Fúlvio Borges; Rosa, Fabiana Paim

doi:10.1590/0366-69132020663782707

Cited by 2 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This demonstrates that the scaffolds have physical-chemical characteristics, topography, 3D architecture and porosity favorable to tissue neoformation, as proposed by Karageorgiou and Kaplan [7] and Tumedei, Savadori and Del Fabbro [1] and demonstrated in previous studies [23,32,33]. Furthermore, throughout the experiment, these scaffolds were not encapsulated, unlike the studies that evaluated particulate or microsphere biomaterials [29,[38][39][40][41]. Encapsulation would cause the scaffolds to have limited regenerative potential, with the formation of fibrosis surrounding biomaterials.…”

Section: Discussionmentioning

confidence: 54%

Bone regeneration using Wollastonite/β-TCP scaffolds implants in critical bone defect in rat calvaria

Santos¹,

Miguel²,

Barbosa³

et al. 2021

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

In order to provide favorable conditions for bone regeneration, a lot of biomaterials have been developed and evaluated, worldwide. Composite biomaterials have gained notoriety, as they combine desirable properties of each isolated material. Thus, in this research, bone repair capacity of three developed formulations of ceramic scaffolds were evaluated histomorphometrically, after implantation. Scaffolds were based on wollastonite (W) and β-tricalcium phosphate (β-TCP) composites in three different ratios (wt.%). Thirty Wistar rats were randomly assigned to three experimental groups: W-20 (20 W/80β-TCP wt.%), W-60 (60 W/40β-TCP wt.%), and W-80 (80 W/20β-TCP wt.%), evaluated by optical microscopy at biological tests after 15 and 45 days of implantation. Throughout the study, the histological results evidenced that the scaffolds remained at the implantation site, were biocompatible and presented osteogenic potential. The percentage of neoformed mineralized tissue was more evident in the W-20 group (51%), at 45 days. The composite of the W-80 group showed more evident biodegradation than the biomaterials of the W-20 and W-60 groups. Thus, it is concluded that the scaffold containing 20 W/80β-TCP (wt.%) promoted more evident bone formation, but all composites evaluated in this study showed notorious bioactivity and promising characteristics for clinical application.

show abstract

Section: Discussionmentioning

confidence: 54%

Bone regeneration using Wollastonite/β-TCP scaffolds implants in critical bone defect in rat calvaria

Santos¹,

Miguel²,

Barbosa³

et al. 2021

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

show abstract

“…Research in the area of bone tissue engineering has focused on critical bone defects, due to the challenge of regenerating this type of defect, and also due to the formation of fibrotic scars and bone neoformation limited to the margins of the defects (Cardoso et al, 2006;Miguel et al, 2006;Miguel et al, 2013;Ribeiro et al, 2015;Santos et al, 2019;Almeida et al, 2020;Santos et al, 2021;Lappalainen et al, 2015). From chart 1, it is possible to notice the lack of standardization of the size of the defect considered critical in experimental works.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite, alginate and gelatin composites used for bone regeneration: a systematic review

Santos

Santos²,

Miguel³

et al. 2023

RSD

View full text Add to dashboard Cite

Aim: to investigate and describe, through a systematic review, the biological behavior and osteogenic potential of composite biomaterials containing hydroxyapatite (HA), alginate and gelatin, in different associations, after in vivo implantation. Materials and Methods: for the search and selection of articles, the Medical Literature Analysis and Retrieval System Online (PubMed/MEDLINE) and Scientific Electronic Library Online (SciELO) databases were used, published between 2012 and 2022, using the descriptors: “bone regeneration”; “biocompatible material”; “durapatite”; “alginate”; “gelatin”. Initially, an association was made with the Boolean operator "OR" between the descriptors and their respective entry terms, considering that the MeSH and DeCS platforms use different terms to refer to the same keywords. Subsequently, the "AND" operator was used in nine associations between the descriptors. Results: during the searches, 1939 articles were located. After using the inclusion and exclusion criteria, 16 studies were included in the review. The main themes found in the searches were: HA and Alginate; HA and Gelatin; HA, Alginate and Zinc; HA, Gelatin and mesenchymal cells; HA, Alginate and Chitosan; HA, Alginate and Silk Fibrin; HA, Gelatin and titanium dioxide; HA, Alginate and Gelatin. It was observed that HA, when associated with alginate or gelatin, has improved its osteogenic properties. Final Considerations: HA composites associated with alginate and gelatin provide a range of applications and promising strategies applied to bone repair. Studies have shown that these composites have great potential for application in Bone Tissue Bioengineering.

show abstract

Regeneração de defeito ósseo crítico após implantação de fosfato de cálcio bifásico (β-fosfato tricálcico/pirofosfato de cálcio) e vidro bioativo fosfatado

Cited by 2 publications

References 28 publications

Bone regeneration using Wollastonite/β-TCP scaffolds implants in critical bone defect in rat calvaria

Bone regeneration using Wollastonite/β-TCP scaffolds implants in critical bone defect in rat calvaria

Hydroxyapatite, alginate and gelatin composites used for bone regeneration: a systematic review

Contact Info

Product

Resources

About