Regarding micro-RNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints

Liebling, Michael R.

doi:10.1136/annrheumdis-2019-215454

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…[373] By targeting genes that are known to exacerbate inflammation or contribute to cartilage degeneration, such as MMPs or inflammatory cytokines, ASOs effectively mitigate joint inflammation and slow down the progression of cartilage damage. [374,375] These advances in RNA-based therapies, facilitated by the unique properties of circRNAs, lncRNAs, ASOs, and an-tagomiRNA, open new avenues in OA treatment, highlighting the potential of these molecules in revolutionizing therapeutic approaches.…”

Section: Other Non-coding Rnamentioning

confidence: 99%

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Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting disease progression. This review illuminates novel approaches in OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural joint lubrication, show promise in restoring joint biomechanics and alleviating pain. The review delves into an array of biomimetic lubricants, including polymer brush, nanocomposite hydrogel, and nanoparticles, underscoring their roles in anti‐inflammation, targeting, cartilage repair, and drug delivery. Furthermore, the potential of mesenchymal stem cells to differentiate into chondrocytes, coupled with the delivery of these cells and their exosomes via nanomaterials, has promoted cell therapy avenues for OA. The review also highlights the function of non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, and antisense oligonucleotides in impeding OA progression, with nanomaterials facilitating their delivery, thus facilitating advanced therapeutic possibilities including immune evasion and bone cell proliferation. Overall, this review encapsulates the evolution of nanomaterials in OA treatment from material to cell, and ultimately to gene therapy, forecasting a future where nanomaterials evolve toward integrated, personalized diagnostics and therapeutics for OA.

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Section: Other Non-coding Rnamentioning

confidence: 99%

Section: Nanomaterials Supported Non‐coding Rna For Oa Gene Therapymentioning

confidence: 99%

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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“…We wish to thank Dr Liebling for the relevant comments1 regarding our recent article in Annals of the Rheumatic Diseases entitled ‘MicroRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints’ 2. We are delighted that our article has gathered such interest in the scientific community and are happy to provide additional comments.…”

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confidence: 95%

Response to: ‘Regarding microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints’ by Liebling

2019

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Micro-223 Promotes Diabetic Osteoarthritis Progression by Regulating Cartilage Degeneration and Subchondral Bone Remodeling

Li,

Fu,

Zhao

et al. 2023

CARTILAGE

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Objective Our study was performed to investigate whether micro-223 promotes diabetic Osteoarthritis (OA) progression by regulating cartilage degeneration and subchondral bone remodeling. Methods The expression of miR-223 in human normal cartilage, OA cartilage, and subchondral bone tissue with or without DM was detected by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). miR-223 mimic or inhibitor was transfected into chondrocytes. Cell viability and apoptosis were assessed by 3-(4,5)-dimethylthiahiazo(-2)-3,5-diphenyltetrazolium bromide (MTT) and Terminal Deoxynucleotidyl Transferase(TdT)-mediated dUTP nick end labeling (TUNEL) assay, respectively. Results miR-223 was significantly higher in human diabetic OA cartilage and subchondral bone compared with normal OA and healthy control. Overexpression of miR-223 accelerated cartilage degeneration and subchondral bone sclerosis in diabetic OA mice, whereas miR-223 inhibition had the opposite effect. In vitro upregulation of miR-223 decreased proliferation and enhanced apoptosis of chondrocytes. Meanwhile, downregulation of miR-223 promoted glycosaminoglycan (GAG) production in chondrocytes. Conclusion miR-223 promotes diabetic OA progression by regulating cartilage degeneration and subchondral bone remodeling both in vitro and in vivo.

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Regarding micro-RNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints

Cited by 3 publications

References 2 publications

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Response to: ‘Regarding microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints’ by Liebling

Micro-223 Promotes Diabetic Osteoarthritis Progression by Regulating Cartilage Degeneration and Subchondral Bone Remodeling

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