Regarding “Altered fibrin clot structure and function in individuals with intermittent claudication”

Bhasin, Nikhil; Parry, D.J.; Scott, D. J. A.; Ariëns, Robert A. S.; Grant, Peter J.; West, Robert

doi:10.1016/j.jvs.2008.11.028

Cited by 11 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…127 Bhasin et al reported on 34 relatively young patients with mild to moderate PAD in whom plasma fibrin clots were poorly permeable, rigid, and resistant to lysis, with increased fiber thickness. 128 Hypofibrinolysis was associated with a 2.3-fold higher odds ratio of PAD. 129 First-degree relatives of PAD patients showed similar clot characteristics, 130 providing evidence for genetic regulation of fibrin characteristics in PAD.…”

Section: Peripheral Arterial Diseasementioning

confidence: 93%

Fibrin Clot Structure and Function

Undas

Ariëns

2011

ATVB

Self Cite

437

200

View full text Add to dashboard Cite

Abstract-The formation of fibrin clots that are relatively resistant to lysis represents the final step in blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis. Fibrin clots composed of compact, highly branched networks with thin fibers are resistant to lysis. Altered fibrin structure has consistently been reported in patients with several diseases complicated by thromboembolic events, including patients with acute or prior myocardial infarction, ischemic stroke, and venous thromboembolism. Relatives of patients with myocardial infarction or venous thromboembolism display similar fibrin abnormalities. Low-dose aspirin, statins, lowering of homocysteine, better diabetes control, smoking cessation, and suppression of inflammatory response increase clot permeability and susceptibility to lysis. Growing evidence indicates that abnormal fibrin properties represent a novel risk factor for arterial and venous thrombotic events, particularly of unknown etiology in young and middle-aged patients. (Arterioscler Thromb Vasc Biol. 2011;31:e88-e99.)

show abstract

Section: Peripheral Arterial Diseasementioning

confidence: 93%

Fibrin Clot Structure and Function

Undas

Ariëns

2011

ATVB

Self Cite

437

200

View full text Add to dashboard Cite

show abstract

“…74 In 34 relatively young patients with mild to moderate PAD, plasma fibrin clots have also been reported to be poorly permeable, rigid, and resistant to lysis. 75 The most pronounced and typical feature of PAD patients appeared to be increased fiber thickness on turbidimetry. 75 In 2009, Guimaraes et al 76 showed that hypofibrinolysis was associated with a 2.3-fold higher odds ratio of PAD diagnosed at a young age.…”

Section: Fibrin Clot Properties and Cardiovascular Medica-mentioning

confidence: 99%

“…75 The most pronounced and typical feature of PAD patients appeared to be increased fiber thickness on turbidimetry. 75 In 2009, Guimaraes et al 76 showed that hypofibrinolysis was associated with a 2.3-fold higher odds ratio of PAD diagnosed at a young age. Of note, first-degree relatives of PAD patients had similarly altered clot characteristics as the patients, 77 indicating the importance of yet unidentified genetic factors that might be implicated in the pathogenesis of PAD, particularly in younger age groups.…”

Section: Fibrin Clot Properties and Cardiovascular Medica-mentioning

confidence: 99%

Acquired dysfibrinogenemia in atherosclerotic vascular disease

Undas

2011

Polish Archives of Internal Medicine

View full text Add to dashboard Cite

Acquired qualitative abnormalities of fibrinogen molecules, termed acquired dysfibrinogenemia, have been demonstrated in several disease states mostly related to prothrombotic tendency, including multiple myeloma and liver disease. Fibrin is abundant in atherosclerotic plaques. Altered plasma fibrin properties, reflected usually by reduced clot permeability and impaired fibrinolysis, have been reported in patients with acute or prior myocardial infarction, ischemic stroke, and peripheral artery disease. Moreover, prothrombotic clot phenotype has been observed in patients with previous no-reflow phenomenon and stent thrombosis. Growing evidence indicates that acquired dysfibrinogenemia contributes to the progression of atherosclerotic vascular disease and the occurrence of its thrombotic manifestations. The review summarizes current knowledge on the links between fibrin clot phenotype and atherosclerotic vascular disease and describes a wide spectrum of cardiovascular risk factors as modifiers of fibrin network characteristics.

show abstract

“…The potential contribution of erythrocytes to the clot formation process requires further investigation. Previously, others observed denser and faster formed fibrin clots in patients with PAD in comparison to healthy controls (27, 29, 30). However, fibrinogen levels are not always implicated unequivocally (29).…”

Section: Discussionmentioning

confidence: 81%

Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case–Control Study

Kleinegris

Konings

Daemen

et al. 2017

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundIn peripheral arterial disease (PAD), activation of the hemostatic system may contribute to atherosclerosis progression and atherothrombotic events.ObjectiveThis case–control study assesses the overall coagulation status in PAD patients by evaluating coagulation markers in combination with thrombin generation potential, whole blood (WB) clot formation, and fibrinolysis.MethodsIn blood from 40 PAD patients (n = 20 with cardiovascular event within 1 year after initial diagnosis, n = 20 without) and 40 apparently healthy controls, thrombin generation was determined in WB and platelet-poor plasma. Whole blood rotational thromboelastometry (ROTEM) measurements were triggered with tissue factor with/without tissue plasminogen activator.ResultsWe observed increased levels of erythrocyte sedimentation rate, leukocytes, eosinophil granulocytes, vWF antigen, fibrinogen, and D-dimer in PAD patients (p < 0.05). Markers of thrombin generation potential showed no difference between patients and healthy controls. In PAD patients with event compared to patients without, WB-thrombin generation showed a lower thrombin potential when triggered with 0 and 2.5 pM tissue factor. The ROTEM clotting assay showed significantly faster clot formation and increased clot firmness in PAD patients compared to controls. No significant differences were found for parameters of clot degradation.ConclusionThere are no significant differences between the thrombin generation profiles of PAD patients and healthy controls. Between PAD patients with and without cardiovascular event, the WB thrombin generation appears to differ. Mechanistically, PAD patients show an increased ability to form a stable clot in WB in comparison to healthy controls. This is most likely due to the increased fibrinogen levels related to the inflammation in atherosclerosis, confirming the importance of the inflammation-coagulation axis.

show abstract

Regarding “Altered fibrin clot structure and function in individuals with intermittent claudication”

Cited by 11 publications

References 6 publications

Fibrin Clot Structure and Function

Fibrin Clot Structure and Function

Acquired dysfibrinogenemia in atherosclerotic vascular disease

Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case–Control Study

Contact Info

Product

Resources

About