Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

Baxa, Jan; Hromádka, Milan; Šedivý, J.; Stepankova, Lucie; Moláček, Jiří; Schmidt, Bernhard; Flohr, Thomas; Ferda, Jiří

doi:10.1155/2015/105629

Cited by 16 publications

(10 citation statements)

References 29 publications

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“… 8 , 11 Furthermore, SAFIRE has been applied to diagnostic 4-dimensional CT for chronic obstructive pulmonary disease 15 and coronary artery stenosis. 16 …”

Section: Introductionmentioning

confidence: 99%

Reducing radiation dose and enhancing imaging quality of 4DCT for radiation therapy using iterative reconstruction algorithms

Noid

Tai

Chen

et al. 2017

Advances in Radiation Oncology

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PurposeFour-dimensional computed tomography (CT) images are typically used to quantify the necessary internal target volumes for thoracic and abdominal tumors. However, 4-dimensional CT is typically associated with excessive imaging dose to patients and the situation is exacerbated when using repeat 4-dimensional CT imaging on a weekly or daily basis throughout fractionated therapy. The aim of this work is to evaluate an iterative reconstruction (IR) algorithm that helps reduce the imaging dose to the patient while maintaining imaging quality as quantified by point spread function and contrast-to-noise ratios (CNRs).Methods and materialsAn IR algorithm, SAFIRE, was applied to CT data of a phantom and patients with varying CT doses and reconstruction kernels. Phantom data enable measurements of spatial resolution, contrast, and noise. The impact of SAFIRE on 4-dimensional CT was assessed with patient data acquired at 2 different dose levels during image guided radiation therapy with an in-room CT.ResultsPhantom data demonstrate that IR reduces noise approximately in proportion to the number of iterations indicated by the strength (SAFIRE 1 to SAFIRE 5). Spatial resolution and contrast are conserved independent of dose and reconstruction parameters. The CNR increases with an increase of imaging dose or an increase in the number of iterations. The use of IR on CT sets confirms the results that were derived from phantom scans. The IR significantly enhances single breathing phase CTs in 4-dimensional CT sets as assessed by CT number discrimination. Furthermore, the IR of the low dose 4-dimensional CT features a 45% increase in the CNR in comparison with the standard dose 4-dimensional CT.ConclusionsThe use of IR algorithms reduces noise while preserving spatial resolution and contrast, as evaluated from both phantom and patient CT data sets. For 4-dimensional CT, the IR can significantly improve image quality and reduce imaging dose without compromising image quality.

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“… 8 , 11 Furthermore, SAFIRE has been applied to diagnostic 4-dimensional CT for chronic obstructive pulmonary disease 15 and coronary artery stenosis. 16 …”

Section: Introductionmentioning

confidence: 99%

Reducing radiation dose and enhancing imaging quality of 4DCT for radiation therapy using iterative reconstruction algorithms

Noid

Tai

Chen

et al. 2017

Advances in Radiation Oncology

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“…A potential disadvantage of regadenoson is the higher heart rate compared with other vasodilators, which may lead to more motion artifacts during CTP acquisition. However, regadenoson tends to be better tolerated and has been tested in single center CTP studies [43][44][45] and a randomized diagnostic accuracy study that compared CTP and SPECT myocardial perfusion imaging. 26 Overall, regadenoson was similarly tolerated in regards to adverse events between CTP and SPECT imaging.…”

Section: The Use Of Pharmacologic Stress Agents Aminophylline and Nimentioning

confidence: 99%

Society of cardiovascular computed tomography expert consensus document on myocardial computed tomography perfusion imaging

Patel

Bamberg

Branch

et al. 2020

Journal of Cardiovascular Computed Tomography

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“…Image acquisition for myocardial CTP can be performed as a standard, static scan starting after a pre-defined delay or as a dynamic scan using two alternating table positions ("shuttle-mode"). This "shuttle-mode" technique allows visualization of CM bolus over a longer time period (43). Further research is necessary to elucidate the additional impact of this increased radiation exposing technique.…”

Section: Stress Myocardial Ctpmentioning

confidence: 99%

Advances in cardiac CT contrast injection and acquisition protocols

Scholtz

Ghoshhajra

2017

Cardiovasc. Diagn. Ther.

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Cardiac computed tomography (CT) imaging has become an important part of modern cardiovascular care. Coronary CT angiography (CTA) is the first choice imaging modality for non-invasive visualization of coronary artery stenosis. In addition, cardiac CT does not only provide anatomical evaluation, but also functional and valvular assessment, and myocardial perfusion evaluation. In this article we outline the factors which influence contrast enhancement, give an overview of current contrast injection and acquisition protocols, with focus on current emerging topics such as pre-transcatheter aortic valve replacement (TAVR) planning, cardiac CT for congenital heart disease (CHD) patients, and myocardial CT perfusion (CTP). Further, we point out areas where we see potential for future improvements in cardiac CT imaging based on a closer interaction between CT scanner settings and contrast injection protocols to tailor injections to patient- and exam-specific factors.

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Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

Cited by 16 publications

References 29 publications

Reducing radiation dose and enhancing imaging quality of 4DCT for radiation therapy using iterative reconstruction algorithms

Reducing radiation dose and enhancing imaging quality of 4DCT for radiation therapy using iterative reconstruction algorithms

Society of cardiovascular computed tomography expert consensus document on myocardial computed tomography perfusion imaging

Advances in cardiac CT contrast injection and acquisition protocols

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