Abstract:Background and Purpose: Tacrolimus (Tac) induces pancreatic β cell
dysfunction, causing new-onset diabetes mellitus (NODM) after
transplantation. Reg3g is a member of the pancreatic regenerative gene
family, as reported to improve type 1 diabetes by promoting β cell
regeneration. Here, we aim to investigate the role and approach of Reg3g
in reversing Tac-induced β cell dysfunction and NODM in mice.
Experimental Approach: Circulating REG3A (the human homolog of mouse
Reg3g) concentrations of patients treated wi… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.