REG Iα is a Reliable Marker of Chemoradiosensitivity in Squamous Cell Esophageal Cancer Patients

Hayashi, Kaori; Motoyama, Satoru; Sugiyama, Toshihiro; Izumi, Junichi; Anbai, Akira; Nanjo, Hiroshi; Watanabe, Hitoshi; Maruyama, Kiyotomi; Minamiya, Yoshihiro; Koyota, Souichi; Koizumi, Yukio; Takasawa, Shin; Murata, Katsuyuki; Ogawa, Jun–ichi

doi:10.1245/s10434-008-9810-8

Cited by 24 publications

(15 citation statements)

References 36 publications

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“…Hayashi et al reported that Reg IA expression might be a marker of long-term survival in patients with locally advanced thoracic esophageal squamous cell carcinoma treated with neoadjuvant definitive chemoradiotherapy followed by planned esophagectomy; they observed that patients with Reg IA-positive tumors were responsive to the chemoradiothrapy, which often provided a complete response and longterm survival (109).…”

Section: Mitogenesis and Cancermentioning

confidence: 99%

Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases

Jin

Hayakawa

et al. 2011

Intern. Med.

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Pancreatic stone protein (PSP; reported in 1979), pancreatitis-associated protein (PAP; 1984) and regenerating protein (Reg I;1988) were discovered independently in the fields of the exocrine (pancreatitis) and endocrine (diabetes) pancreas. Subsequent analysis revealed that PSP and Reg I are identical and PAP belongs to the same protein family. PSP/Reg I and PAP share a selective and specific trypsin cleavage site and result in insoluble fibrils (PTP, PATP). Search for a functional role of PSP had led to the idea that it might serve as an inhibitor in pancreatic stone formation and PSP was renamed lithostathine. Inhibitory effects of lithostathine in stone formation have been questioned. Evidence so far obtained can support a lithogenic role rather than a lithostatic role of PSP. PAP and its isoforms have been investigated mainly regarding responses to inflammation and stress. Reg I and its isoforms have been examined on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases as well as diabetes. Evidence obtained can be applied in the prediction of prognosis and therapy for inflammatory and neoplastic diseases.

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Section: Mitogenesis and Cancermentioning

confidence: 99%

Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases

Jin

Hayakawa

et al. 2011

Intern. Med.

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“…In chemotherapy, cells were treated with cisplatin (Nihonkayaku Co., Tokyo, Japan) at concentration of 1.0 or 10 µM. Chemosensitivity was assessed by Cell Counting Kit-8 (WST-8 cleavage; Dojindo, Mashikimachi, Japan) as described previously (23). The cell viability after the chemotherapy for the cells was evaluated with the WST-8 cleavage.…”

Section: Introductionmentioning

confidence: 99%

Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells

Masui

Ota

Yook

et al. 2013

International Journal of Oncology

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Abstract. Head and neck squamous cell carcinoma (HNSCC) is known to have a poor prognosis. The resistance to treatment and distant metastasis are important clinical problems in HNSCC. The epithelial-mesenchymal transition (EMT) is a key process in successful execution of many steps such as the invasion and metastasis for cancer cells. Snail is one of the master regulators that promote EMT in many types of malignancies including HNSCC. Recently, it has been shown that Snail-induced EMT could induce a cancer stem cell (CSC)-like phenotype in a number of tumor types. In this study, we investigated the role of Snail in inducing EMT properties and CSC-like phenotype in HNSCC. We established HNSCC cell lines transfected with Snail. E-cadherin was analyzed using western blot analysis and immunofluorescence staining. Cell migration and invasion were assessed using wound-healing assay and modified Boyden chamber assay, respectively. CSC markers of HNSCC, CD44 and aldehyde dehydrogenase 1 (ALDH1), were also evaluated with western blot analysis, and chemosensitivity was assessed with WST-8 assay. Introduction of Snail induced EMT properties in HNSCC cells and enhanced cell migration and invasion. Moreover, Snail-induced EMT gained CSC-like phenotype and was associated with increased chemoresistance. These results suggest that Snail could be one of the attractive targets for the development of therapeutic strategies in HNSCC.

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“…We previously reported that REG1A is a reliable sensitivity marker in ESCC patients (clinical T4) treated with neoadjuvant CRT [33] or definitive CRT [34]. We also recently showed that among stage II and III ESCC patients treated with esophagectomy followed by adjuvant chemotherapy, OS, DSS and DFS were all significantly better in REG1A-positive than REG1A-negative patients [35].…”

Section: Positive Biomarkers In Tissue Examinationmentioning

confidence: 99%

Novel Candidate Biomarkers of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma: A Systematic Review

Sato

Motoyama²,

Saito³

et al. 2016

Eur Surg Res

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There is no doubt that, along with surgery, chemoradiotherapy is an important treatment for esophageal squamous cell carcinoma (ESCC). Patients who respond well to chemoradiotherapy obtain great benefits toward overcoming their cancer, and so a more favorable prognosis. On the other hand, patients who do not respond well have wasted valuable time and experienced severe toxicity and seriously diminished quality of life, only to have their cancer recur with an unfavorable prognosis. For this reason, a reliable biomarker of chemoradiosensitivity in ESCC has long been sought. In this review, we will enumerate recently reported candidate biomarkers of chemoradiosensitivity in ESCC that have the potential for future clinical application.

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REG Iα is a Reliable Marker of Chemoradiosensitivity in Squamous Cell Esophageal Cancer Patients

Abstract: REG Ialpha expression in squamous cell esophageal carcinoma may be a reliable marker of chemoradiosensitivity. We anticipate that it will enable us to provide more appropriate and individualized treatment to patients of advanced esophageal squamous cell carcinoma.

Cited by 24 publications

References 36 publications

Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases

Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases

Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells

Novel Candidate Biomarkers of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma: A Systematic Review

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