Spiritual intelligence relates to one's ability to rely on the ultimate power to determine his or her success in worldly affairs including entrepreneurship orientation. The Previous researchers agreed that spiritual intelligence has three dimensions comprising rituals, forgiveness, and beliefs whereas entrepreneurship orientation is divided into three, constituting proactive, innovative, and risk-taking. Some researchers discovered that spiritual intelligence is directly related to entrepreneurship orientation, but the findings are inconsistent from one study to another. Therefore, the present study is meant to investigate the role of locus of control in affecting the relationship between spiritual intelligence and entrepreneurship orientation. Using 319 data collected from entrepreneurs, the results of moderated multiple regression analysis revealed that locus of control moderates the relationship between rituals and risk-taking and between forgiveness and risk-taking. The findings indicate that entrepreneurs' risk-taking can be enhanced by increasing the level of rituals and forgiveness of entrepreneurs. The relationship can be improved by having a low external locus of control. The implication of the study is discussed in the paper.