Refractory pure red cell aplasia associated with B-CLL: successful treatment with a combination of fludarabine, cyclosporin A and erythropoietin

Shimoni, Avichai; Shvidel, Lev; Klepfish, Abraham; Shtalrid, Mordechai; Sigler, Erica; Berrébi, Alain

doi:10.1038/sj.leu.2401252

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a few reports suggesting that the treatment of CLL with FA may induce PRCA in patients with this disease (Leporrier et al , 1993). On the other hand, FA may be helpful in the treatment of PRCA secondary to CLL (Jaccard et al , 1993; Ribeiro et al , 1999; Shimoni et al , 1999). The influence of 2‐CdA on the PRCA in CLL patients is even less understood.…”

Section: Clinical Features and Response To Therapy Of Eight Patients mentioning

confidence: 99%

Correspondence

et al. 2001

View full text Add to dashboard Cite

Keywords: myelofibrosis, children, spontaneous remission. PURE RED CELL APLASIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA TREATED WITH CLADRIBINEPure red cell aplasia (PRCA) is a rare haematological syndrome with severe anaemia, reticulocytopenia and the absence of red blood cell precursors in the bone marrow, associated with quantitatively and qualitatively normal megakaryocytic and myeloid cell lines (Chikkappa et al, 1986). It occurs in approximately 6% of chronic lympho-

show abstract

Section: Clinical Features and Response To Therapy Of Eight Patients mentioning

confidence: 99%

Correspondence

et al. 2001

View full text Add to dashboard Cite

show abstract

“…PRCA was reported to develop in as many as 6% of patients with CLL (Chikkappa et al , 1986). There are several reports showing resolution of CLL‐associated PRCA after fludarabine treatment (Jaccard et al , 1993; Serra et al , 1999; Shimoni et al , 1999). Alternatively, Leporrier et al (1993) reported PRCA that developed during treatment of CLL with fludarabine.…”

mentioning

confidence: 99%

A case of refractory idiopathic pure red cell aplasia responsive to fludarabine treatment

Ahn¹,

Lee²,

Lee³

et al. 2001

Br J Haematol

View full text Add to dashboard Cite

Autoimmune cytopenias in chronic lymphocytic leukemia: a concise review and treatment recommendations

Back

Kater

Tonino

2018

Expert Review of Hematology

View full text Add to dashboard Cite

Chronic lymphocytic leukemia (CLL) is frequently complicated by cytopenias, either due to bone marrow infiltration or autoimmunity, resulting in autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia (PRCA), or autoimmune neutropenia (AIN). Morbidity due to autoimmune cytopenias (AIC) can be substantial; in addition, infection risk increases and pre-existing infections might deteriorate due to immunosuppressive medication. In the aging population, CLL occurs more frequently and AIC related to CLL represent a growing clinical challenge. Areas covered: This review summarizes current knowledge on pathophysiological mechanisms involved in AIC development and their prognostic significance. It provides diagnostic criteria and a treatment guideline for daily clinical practice, which includes the role of novel targeted agents. Expert commentary: The pathophysiology of AIC involves loss of self-tolerance, antigen presentation by malignant CLL cells, and autoantibody production through aberrant T- and B-cell function. The value of detecting autoantibodies via the direct antiglobulin test (DAT) is disputable, since a positive test does not imply overt hemolysis. Importantly, AIC should be distinguished from infiltrative cytopenias, because of prognostic and therapeutic consequences. Compared to chemotherapy, triggering AIC by targeted therapies is less common and, hence, these agents may be valuable as treatment for CLL-related immune cytopenias.

show abstract

Refractory pure red cell aplasia associated with B-CLL: successful treatment with a combination of fludarabine, cyclosporin A and erythropoietin

Cited by 3 publications

References 4 publications

Correspondence

Correspondence

A case of refractory idiopathic pure red cell aplasia responsive to fludarabine treatment

Autoimmune cytopenias in chronic lymphocytic leukemia: a concise review and treatment recommendations

Contact Info

Product

Resources

About