Refractory iron-deficiency anaemia due to silent Helicobacter pylori gastritis in children

Kostaki, Maria; Fessatou, Smaragdi; Karpathios, Themistocles

doi:10.1007/s00431-002-1139-x

Cited by 62 publications

(40 citation statements)

References 26 publications

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“…A potential link between H. pylori and Fe-deficiency anaemia was first proposed in 1990 (4) and supported by a series of case reports (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . Additional evidence was provided by five well-designed cross-sectional studies (16)(17)(18)(19)(20) , although two further studies failed to detect an association (53,54) .…”

Section: Discussionmentioning

confidence: 89%

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Santos

Boccio

Davidsson

et al. 2009

Public Health Nutr.

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Objective: To investigate the association between Helicobacter pylori infection and anaemia. Design: Six cross-sectional studies. H. pylori infection was assessed by the [ 13 C]urea breath test using MS or IR analysis. Hb was measured for all countries. Ferritin and transferrin receptors were measured for Argentina, Bolivia, Mexico, and Venezuela. Setting: Health services in Argentina, Brazil and Mexico or public schools in Bolivia, Cuba and Venezuela. Subjects: In Argentina, 307 children aged 4-17 years referred to a gastroenterology unit; in Bolivia, 424 randomly selected schoolchildren aged 5-8 years; in Brazil, 1007 adults (157 men, 850 women) aged 18-45 years attending thirty-one primary healthcare units; in Cuba, 996 randomly selected schoolchildren aged 6-14 years; in Mexico, seventy-one pregnant women in their first trimester attending public health clinics; in Venezuela, 418 children aged 4-13 years attending public schools. Results: The lowest prevalence of H. pylori found was among children in Argentina (25?1 %) and the highest in Bolivia (74?0 %). In Bolivia, Cuba and Venezuela children showed similar prevalence of H. pylori infection as in Brazilian and Mexican adults (range 47?5 % to 81?8 %). Overall anaemia prevalence was 11?3 % in Argentina, 15?4 % in Bolivia, 20?6 % in Brazil, 10?5 % in Cuba and 8?9 % in Venezuela. Adjusted analyses allowing for confounding variables showed no association between H. pylori colonization and anaemia in any study. Hb, ferritin and transferrin receptor levels were also not associated with H. pylori infection in any country.

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Section: Discussionmentioning

confidence: 89%

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Santos

Boccio

Davidsson

et al. 2009

Public Health Nutr.

View full text Add to dashboard Cite

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“…The present study is limited in that H. pylori infection assessment was related to previous exposure (47)(48)(49) , thereby precluding comparisons with studies evaluating current infection. However, in various epidemiological studies and case reports in which H. pylori was shown to be independently associated with iron status, the association emerged primarily among older children (16,19,(20)(21)(22)(23)50) . For example, among the natives of Alaska, H. pylori was independently associated with ID for children aged 9 years and above, but not in younger age groups (16) .…”

Section: Discussionmentioning

confidence: 99%

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Pacey

Weiler

Egeland

2010

Public Health Nutr.

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Objective: To report the prevalence rates and correlates for anaemia, iron deficiency (ID) and iron-deficiency anaemia (IDA) among Inuit preschool-aged children. Design: A cross-sectional study assessed iron intake, demographic information, medical history, anthropometrics, Hb, ferritin, C-reactive protein and antibodies to Helicobacter pylori. Setting: Sixteen selected Inuit communities in Nunavut Territory, Canada. Subjects: Inuit (n 388) aged 3-5 years randomly recruited from communities. Results: Anaemia (3-4 years: Hb , 110 g/l; 5 years: Hb , 115 g/l) was prevalent in 16?8 % of children. The prevalence of ID (ferritin , 12 mg/l) was 18?0 % and that of IDA was 5?4 %. When ID was defined as ferritin ,10 mg/l, 10?8 % of children were iron deficient and 3?3 % had IDA. In multiple logistic regression, boys were more likely to be iron deficient (OR 5 2?28, 95 % CI 1?17, 8?25), but no other risk factor emerged for ID. Three-to 4-year-olds were less likely than 5-year-olds to have anaemia from causes other than ID (OR 5 0?11, 95 % CI 0?08, 0?58). Anaemia from other causes was more common among children residing in crowded homes (OR 5 2?30, 95 % CI 1?37, 12?31) and those treated for past-year ear infection (OR 5 1?35, 95 % CI 1?05, 7?21). Conclusions: The low prevalence of ID and IDA is encouraging, but efforts are still needed to reduce rates as they continue to be higher than general population rates. Household crowding and infections may contribute to anaemia and warrant further research.

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“…It appears that chronic gastrointestinal blood loss is not the likely culprit, since most published cases and case series found no bleeding lesions after investigation and the subjects had negative faecal occult blood testing. 6,7 A more likely mechanism is decreased iron absorption from hypo or achlorhydria resulting from chronic gastritis. 8 Person with H. pylori infection and IDA appear more likely to have corpus gastritis as compared to H. pylori infected patients without anaemia, which results in decreased gastric acid secretion and increase in intragastric pH that may impair iron absorption.…”

Section: Hb (Gm%)mentioning

confidence: 99%

Role of Anti-Helicobacter Pylori Therapy in Iron Deficiency Anaemia- A Prospective Study

Parambil¹,

Shahulhameed²

2017

jemds

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BACKGROUNDAccumulating evidence suggests that Helicobacter pylori (H. Pylori) infection account for many unexplained cases of Iron Deficiency Anaemia (IDA), which may benefit from testing and treatment for H. pylori infection. This study attempts to evaluate the role of anti H. pylori treatment in management of iron deficiency anaemia among patients treated at a tertiary care centre in North India. MATERIALS AND METHODSThis was a prospective study which included 60 patients with IDA, proven positive for H. pylori by Rapid urease test and histopathological staining. They were divided into three groups (n= 20) and received different treatments, i.e. only anti-H. pylori therapy/ oral iron therapy plus anti-H. pylori therapy/ only oral iron therapy. Haemoglobin, RBC indices, Reti count, S. iron and S. ferritin were compared at the end of treatment with One-Way ANOVA.

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Refractory iron-deficiency anaemia due to silent Helicobacter pylori gastritis in children

Abstract: Iron-deficiency anaemia may be due to clinically inapparent H. pylori gastritis.

Cited by 62 publications

References 26 publications

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

Role of Anti-Helicobacter Pylori Therapy in Iron Deficiency Anaemia- A Prospective Study

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