Refractory Hypocalcemia Effectively Treated with Steroids in Prostate Cancer Metastatic to Bone

Severe and refractory hypocalcaemia secondary to osteoblastic bone metastases in bladder signet ring carcinoma: A case report and literature review

“…[ 46 ] It has been used for the management of hypocalcaemia with mixed response. [ 22 , 25 ] In our patient, he remained hypocalcaemic despite 2 weeks of IV calcium infusion in addition to high doses of calcium, vitamin D, and calcitriol replacement. Unfortunately, he was not a candidate for chemotherapy or radionuclide therapy due to his poor prognosis and functional status.…”

“…Lim et al [17] 80 yo/M Prostate Vit D resistance Calcium and Vit D replacement Unknown 2005 Fokkema at al [18] 67 yo/M Prostate Vit D deficiency Calcium and Vit D replacement Adenocarcinoma Acute kidney injury Androgen deprivation therapy 2008 Yener et al [19] 70 yo/M Prostate Vit D deficiency Calcium and Vit D replacement Adenocarcinoma Androgen deprivation therapy 2008 Pusulari et al [20] 65 yo/M Prostate Nil Not known Unknown 2015 Rizzo et al [21] 72 yo/M Prostate Vit D deficiency Calcium and Vit D replacement Unknown Acute kidney injury Androgen deprivation therapy Relative hypoparathyroidism 2017 Gebara et al [22] 71 yo/M Prostate Vit D deficiency Ca and Vit D replacement Adenocarcinoma Steroid 2017 Diéguez et al [23] 84 yo/M Prostate Vit D deficiency Calcium and Vit D replacement Adenocarcinoma Androgen deprivation therapy 2018 Garla et al [24] 50 yo/M Prostate Vit D deficiency Ca and Vit D replacement Unknown Radium 223 dichloride 2020 Drekolias et al [25] 61 yo/M Prostate Nil Ca and Vit D replacement Adenocarcinoma Chemotherapy and radiotherapy IV steroid CKD = chronic kidney disease, Hx = history, IV = intravenous, vit D = vitamin D, yo = years old. www.md-journal.com hypocalcaemia in malignancy.…”