Refractory Erosive Oral Lichen Planus Associated with Hepatitis C: Response to Topical Tacrolimus Ointment

Abstract

This case supports the safety and efficacy of topical tacrolimus in patients with steroid-refractory OLP associated with chronic hepatitis C.

Calcineurin inhibitors in oral medicine

“…85 Indeed, topical tacrolimus has been used safely in patients with hepatic disease (active hepatitis C or hepatic cirrhosis). 14,15,86 As observed in patients with AD, 87 absorption of tacrolimus after local application for OLP seems to decrease as disease resolves and mucosal integrity returns. 19 The absorption associated with OLP seems to be greater than that associated with AD.…”