Refractory chylous pleural effusion with systemic lupus erythematosus

Song, Peng; Zhang, JingCheng; Shang, Congcong; Zhang, Li

doi:10.1007/s00393-018-0545-z

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Two studies reported the occurrence of chylothorax at 120 and 20 to 120 months, respectively, after the diagnosis. 9 , 10 Our patient shared this characteristic as he was diagnosed 86 months prior. However, more extensive studies are required to understand the risk conferred by these factors through multivariate regression analyses, as selection bias cannot be excluded with this sample size.…”

Section: Discussionsupporting

confidence: 59%

“… 6 The observed refractoriness could be linked to lymphoscintigraphy findings of residual adhesions or thoracic duct obstructions that persist after SLE systemic inflammation’s resolution. 10 Surgical procedures may be needed in these cases and have shown better responses than medical therapy alone. In our case, medical treatment was ineffective in the short-term follow-up but achieved remission in the long term.…”

Section: Discussionmentioning

confidence: 99%

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Massive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review

Corredor-Orlandelli,

Arévalo-Romero,

Reyes

et al. 2023

Clin Med Insights Case Rep

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This case report describes a 23-year-old male patient who presented with right chylothorax as the initial manifestation of a severe flare of systemic lupus erythematosus (SLE) and secondary Evans syndrome. Chylothorax and chylous ascites are rare features of SLE that can occur due to the accumulation of triglyceride-rich fluid in serous cavities. However, they have never been reported as the initial manifestation of a lupus flare. Evans syndrome is a rare disease characterized by autoimmune hemolytic anemia and immune thrombocytopenia, which can be secondary to SLE. The concomitant occurrence of both chylothorax and Evans syndrome in the setting of systemic lupus erythematosus has never been described, and the exact causative mechanisms of both entities are yet to be fully understood. In this report, we discuss our approach to this challenging case to broaden the understanding of the clinical manifestations of systemic lupus erythematosus. Our findings emphasize the importance of considering rare features of systemic lupus erythematosus and secondary diseases when evaluating patients with the disease.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Massive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review

Corredor-Orlandelli,

Arévalo-Romero,

Reyes

et al. 2023

Clin Med Insights Case Rep

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“…8,10 But refractory cases to the previous treatment were documented, and, in such cases, intravenous immunoglobulin was considered, and some cases responded well to talc pleurodesis and surgical pleurectomy. 5,18 In this case, the patient responded to rituximab with clinical and radiological improvement. Few similar cases were documented, as in a case reported by Ocampo V et al, 19 in which a 22-year-old male with SLE developed recurrent pericardial and massive unilateral pleural effusion and responded well to tocilizumab.…”

Section: Discussionmentioning

confidence: 71%

A Case Report of Massive Unilateral Pleural Effusion in a Patient with Systemic Lupus Erythematosus Responded to Rituximab

Khatieb¹,

Abushama²,

Adam³

et al. 2020

Exploratory Research and Hypothesis in Medicine

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Systemic lupus erythematosus (SLE) is a systemic disease which affects mainly young females and can cause lifethreatening conditions. Pleural effusion can occur in SLE patients and usually tends to be mild and bilateral. This report aims to highlight the clinical presentation and medical management of massive unilateral pleural effusions in SLE patients. Here we report a 35-year-old female diagnosed with SLE for six years. She presented with shortness of breath, severe pleuritic chest pain, and fatigue. Her clinical examination showed signs of massive pleural effusion on the right side which was confirmed later by a chest x-ray and computer tomography of the chest. An echocardiography and abdominal ultrasound indicated no pericardial effusion and no ascites. A pleural fluid analysis showed exudative fluid. Sputum culture and polymerase chain reaction on blood sample for Mycobacterium tuberculosis were negative. She was also edematous and pale but not cyanotic or jaundiced. The treatment included blood transfusions, antibiotics, rituximab, azathioprine, and hydroxychloroquine. The pleural effusion responded well to rituximab, and she was discharged after two months in good condition.

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Refractory systemic lupus erythematosus with chylous effusion successfully treated with sirolimus: a case report and literature review

et al. 2023

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Refractory chylous pleural effusion with systemic lupus erythematosus

Cited by 6 publications

References 11 publications

Massive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review

Massive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review

A Case Report of Massive Unilateral Pleural Effusion in a Patient with Systemic Lupus Erythematosus Responded to Rituximab

Refractory systemic lupus erythematosus with chylous effusion successfully treated with sirolimus: a case report and literature review

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