Refractive stability of a new single-piece hydrophobic acrylic intraocular lens and corneal wound repair after implantation using a new automated intraocular lens delivery system

Abstract

To investigate refractive stability and characterize corneal incision repair up to 3 months after implantation of a new hydrophobic acrylic intraocular lens (IOL) with hydroxyethylmethacrylate using a new automated IOL delivery system. Methods This prospective case series included 50 eyes of 50 patients undergoing phacoemulsification and implantation of the Clareon ® CNA0T0 IOL using the AutonoMe ® automated delivery system in the Department of Ophthalmology, Keio University School of Medicine. The clinical data were collected from 46 eyes of 46 patients preoperatively and 1 day, 1 week, and 1 and 3 months postoperatively. Endothelial-side incision gaping, posterior incision retraction, and Descemet's membrane detachment were recorded as present or absent using anteriorsegment optical coherence tomography postoperatively. Results The uncorrected distance and corrected distance visual acuities improved and stabilized 1 week postoperatively. The anterior chamber depth was stable from 1 week postoperatively. The subjective refraction was stable from 1 day postoperatively. Descemet's membrane detachments and endothelial-side wound gaping were seen in 19 (41.3%) eyes and 34 (73.9%) eyes 1 day postoperatively and decreased gradually. Posterior incision retraction was seen in eight eyes (17.4%) on day 1 and increased to 19 eyes (41.3%) 3 months postoperatively.

Risk Factor for Transient Hyperopic Refractive Outcome at Acute Postoperative Period After Panoptix Intraocular Lens Implantation

“…The transient hyperopia after cataract surgery has been discussed in the previous literature, with inconsistent outcomes according to the optic-haptic design and IOL materials. [13][14][15][16] In general, one-piece IOLs show more stable ACD than three-piece IOL. 13,14 In addition, a newly introduced IOL (Clareon ® CNA0T0, Alcon Laboratories Inc) that used hydrophilic copolymer and 2-hydroxyethylmethacrylate instead of phenyl-ethyl methacrylate which is used in AcrySof IOL showed stable ACD and SE from postoperative day 1 to month 3.…”

“… 13 , 14 In addition, a newly introduced IOL (Clareon ® CNA0T0, Alcon Laboratories Inc) that used hydrophilic copolymer and 2-hydroxyethylmethacrylate instead of phenyl-ethyl methacrylate which is used in AcrySof IOL showed stable ACD and SE from postoperative day 1 to month 3. 16 …”

“…13,14 In addition, a newly introduced IOL (Clareon ® CNA0T0, Alcon Laboratories Inc) that used hydrophilic copolymer and 2-hydroxyethylmethacrylate instead of phenyl-ethyl methacrylate which is used in AcrySof IOL showed stable ACD and SE from postoperative day 1 to month 3. 16 The accuracy of the modern IOL formula when using a TFNT IOL is favorable. 11 Although the absolute refractive difference between that measured on postoperative day 1 and postoperative month 6 was as small as 0.08 D, the largest amount of the refractive difference was 1.53 D. Because even a small amount of postoperative refractive error can significantly affect visual outcome and patient satisfaction, it would be helpful to discriminate those patients at risk of a transient hyperopic state.…”

Experimental Study on Delivery Performance of an Automated Preloaded Intraocular Lens Injector System for Corneal and Sclerocorneal Incisions

“…Since inadvertently deep insertion of the cartridge nozzle can lead to significant stretch and enlargement of the tissue, it appears that the depth guard contributes to the maintenance of wound size during IOL implantation by limiting too deep insertion [ 5 , 9 , 12 ]. Negishi et al [ 20 ] reported that AutonoMe automated delivery system with the depth guard enabled safe IOL implantation through a 2.4-mm corneal incision. In addition, the presence of depth guard seems to enhance the mechanical strength of the nozzle, which makes the cartridge more resistant to splitting and stretching by suppressing volume increases.…”

Efficacy and Safety Analysis of the New Aspheric Hydrophobic Acrylic Monofocal IOL Implantation at Short-Term Follow-Up

“…В ходе экспериментальных и клинических исследований показано, что новая гидрофобная акриловая ИОЛ не ассоциирована с глистенингом и поверхностным светорассеянием [11][12][13][14]. Эффективность предварительно загруженной системы доставки ИОЛ AutonoMe подтверждена в ряде работ [15][16][17][18]. Вместе с тем в литературе доступно ограниченное число работ с результатами имплантации новой ИОЛ в условиях клинической практики, а в Российской Федерации такие статьи отсутствуют.…”