Refractive growth variability in the Infant Aphakia Treatment Study

Abstract

Purpose: Prediction of refraction after cataract surgery in children is limited by the variance in rate of refractive growth (RRG3). This study compared RRG3 in aphakic and pseudophakic eyes with their fellow, normal eyes in the Infant Aphakia Treatment Study. Setting: Twelve clinical sites in the United States. Design: Randomized clinical trial. Methods: Infants randomized to unilateral cataract extraction had RRG3 calculated based on biometric data (axial length and keratometry) at cataract surgery and at 10 years of age, for both the normal and cataract eyes. Subjects were included if complete biometric data from both eyes were available both at surgery and at 10 years. Variance in RRG3 was compared between the groups with Pitman test for equality of variance between correlated samples. Results: Longitudinal biometric data were available for 103 of the 114 patients enrolled. RRG3 was −15.00 diopters (D) (3.00 D) for normal eyes (reported as mean [SD]), −17.70 D (6.20 D) for aphakic eyes, and −16.70 D (6.20 D) for pseudophakic eyes (P < .0001 for comparison of variances in RRG3 between normal and all operated eyes). Further analysis found differences in the variance in axial length growth (P < .0001) between operated and normal eyes; the variance in keratometry measurement change did not reach significance. Conclusions: The standard deviation in the RRG3 of normal eyes in our study was half of that found in eyes that underwent cataract surgery.

Ten-year outcomes of congenital cataract surgery performed within the first six months of life

“…[7][8][9][10][11] The Infant Aphakia Treatment Study, focusing on patients with unilateral congenital cataract, reported a mean surgical intervention age of 2.3 ± 1.7 months. 21 In the Toddler Aphakia and Pseudophakia Treatment Study Registry, the median age at surgery was 2.5 months (range, 1 to 7 months). 22 Negalur et al reported the surgical results of IOL implantation in infants younger than 6 months, with an average of 5 months (interquartile range 4 to 6 months).…”

Predicting axial length in patients with Marfan syndrome and ectopia lentis after modified capsular tension ring and intraocular lens implantation

“…The age was corrected by adding 0.6 years (corrected age) to modify the asymptotic effects of the log curve around birth and account for the in utero growth of the globe. 11,12 The preAL was the AL measured at the surgery, and the postAL was the AL measured at the final follow-up. We used the rate of AL growth (RALG) to develop a multivariate linear regression model for predicting postoperative AL.RALG=postAL−preALlog⁡10(postAge+0.6)−⁡log⁡10(preAge+0.6)…”

Association Between Preoperative Ocular Parameters and Myopic Shift in Children Undergoing Primary Intraocular Lens Implantation

“… 1 Growth of children's eyeballs following IOL implantation can result in myopic shift over time which exhibits significant interindividual variability. 2 , 3 To prevent high myopia in adulthood, children are usually left moderately hyperopic at the time of IOL implantation. 4 Nevertheless, due to the variability of myopic shift, choosing the optimum postoperative target refraction and IOL power for pediatric patients is still challenging.…”