“…In plants, NLRs function by sensing pathogen-derived virulence molecules, known as effectors, and subsequently activating an immune response (Jacob et al, 2013;Kourelis and van der Hoorn, 2018). The majority of functionally validated NLRs in plants display broadly conserved domain architectures, typically consisting of the NB-ARC (nucleotide-binding adaptor shared by APAF-1, certain R gene products and CED-4) domain, the LRR (leucin-rich repeat) region, and either a TIR (Toll/interleukin 1 receptor), CC (coiled-coil), or CCR (RPW8type CC) domain at the N-terminus (Kourelis and Kamoun, 2020;Shao et al, 2016). However, coevolution with pathogen effectors has led to a remarkable diversification of NLR repertoires, which form one of the most diverse protein families in plants (Lee and Chae, 2020;Prigozhin and Krasileva, 2020).…”