Following the development of globalization, various industries not only in their own country, but also in the whole world, the relationship between peers is closer, the scale of technology exchange, experience exchange, research results exchange is gradually expanding, the gap of applied English talents is increasing, and more demands are put forward for the training and teaching of specialized English skilled personnel. Under the vigorous expansion situation of MOOC and SPOC, this paper introduces the concepts and processes of MOOC and SPOC, and discusses the relationship between them and their respective characteristics and advantages. The author finds that it is this post-MOOC era that provides a rich approach and a new platform for ESP teaching experiments in colleges and universities.