Reflux Nephropathy: A Clinico-Pathological Study of 16 Cases

Abstract

The pathologic features of 16 nephrectomy specimens obtained from patients with a radiological diagnosis of reflux nephropathy were analyzed. Chronic pyelonephritis was diagnosed in 7 cases, renal dysplasia in 5 and segmental atrophy in 4. Clear correlations between pathologic pictures and pathogenic mechanisms involved in the development of renal lesions in kidneys with reflux are difficult to establish. These results show, however, that ‘reflux nephropathy’ is a broad term, which encompasses both congenital and acquired renal lesions.

Vesicoureteral Reflux Causes Interstitial Inflammation in Pediatric Kidney Allograft: A Clinicopathological Analysis of 1-Year Protocol Biopsies

“…Our data also revealed a relationship between interstitial inflammation of mononuclear cells and VUR. A previous report showed lymphocyte invasion in chronic pyelonephritis in reflux nephropathy of native adult and pediatric kidneys [12]. One study reported that tubular atrophy and interstitial fibrosis were found all in five cases from the analysis of end-stage pediatric native CAKUT, congenital anomalies of the kidneys and urinary tracts; eGFR, estimated glomerular filtration rate; THP, Tamm-Horsfall protein; ABMR, antibody-mediated rejection; MRI, medullary ray injury.…”