Reflux laryngitis and its sequelae: The diagnostic role of ambulatory 24-hour pH monitoring

Koufman, James A.; Wiener, Gregory; Wu, Wallace C.; Castell, Donald O.

doi:10.1016/s0892-1997(88)80060-2

Cited by 117 publications

(48 citation statements)

References 26 publications

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“…It causes symptoms such as chronic irritative cough, excessive throat clearing, globus sensation, sore throat, and dysphonia. It has been estimated that 4%-10% of the patients referred to an otolaryngology clinic have symptoms and/or signs related to LPR (2,3). LPR has been found to be related to chronic pharyngitis and laryngitis, contact ulcer, granuloma, subglottic stenosis, vocal fold nodules, and laryngospasm; it is also suggested to be implicated for premalignant lesions and squamous cell carcinoma of the larynx (1,(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The Reflux Finding Score: Reliability and Correlation to the Reflux Symptom Index

Karakaya¹,

Akbulut²,

Altintaş³

et al. 2015

JAREM

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Objective: To evaluate the correlation between the reflux symptom index (RSI) and the reflux finding score (RFS) in the patients with voice-related problems and to investigate the reliability of RFS.Methods: Fifty-four patients presenting with the complaint of voice abnormality were included in the study. Patients were asked to complete an RSI score sheet, and they were examined by rigid laryngostroboscopy. Laryngostroboscopic examinations of the patients were evaluated and rated with RFS by three different otolaryngologists blinded to patient information in two different sessions to evaluate intra-rater and inter-rater reliability. The correlations between RSI and RFS, for both total RFS and individual variables from RFS, were investigated.Results: Sixty-three percent were female and 37% were male, with a mean±SD age of 39.09±14.43 years. RSI ranged from 4 to 31, and RFS ranged from 8 to 22. All three raters demonstrated highly consistent intra-rater and inter-rater reliability for both total RFS and individual variables from RFS. There was a highly significant statistical correlation between RSI and total RFS (r=0.696; p=0.0001). Individual variables from RFS, except the posterior commissure hypertrophy, also demonstrated a significant positive correlation with RSI scores (p<0.05).Conclusion: RFS is a simple scale that could easily be administered with high intra-rater and inter-rater reliability for the evaluation of laryngopharyngeal reflux. RSI is highly correlated with both total RFS and all the individual variables from RFS, except posterior commissure hypertrophy. (JAREM 2015; 5: 68-74)

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Section: Introductionmentioning

confidence: 99%

The Reflux Finding Score: Reliability and Correlation to the Reflux Symptom Index

Karakaya¹,

Akbulut²,

Altintaş³

et al. 2015

JAREM

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“…The distal probe was positioned 5 cm above LES, and the proximal probe near the UES. The patient was examined at home for 24 hours (6,12) . The following parameters were evaluated: number of reflux episodes and percentage of time in which the esophageal pH showed values below 4 units in the two probes and the De Meester index.…”

Section: • Esophageal Manometrymentioning

confidence: 99%

“…It is estimated that 4% to 10% of the patients that seek otorhinolaryngologic service show symptoms of this disease (12) . This paper aimed to analyze the clinical, endoscopic, manometric and pHmetric aspects of patients with GERD and vocal disturbances and to compare them with chronic refluxers without these symptoms.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal reflux disease and vocal disturbances

Henry

Martins

Lerco

et al. 2011

Arq. Gastroenterol.

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CONTEXT: Gastroesophageal reflux disease is a chronic disease in which gastroduodenal contents reflux into the esophagus. The clinical picture of gastroesophageal reflux disease is usually composed by heartburn and regurgitation (typical manifestations). Atypical manifestations (vocal disturbances and asthma) may also be complaint. OBJECTIVE: To analyse the clinical, endoscopic, manometric and pHmetric aspects of patients suffering from gastroesophageal reflux disease associated with vocal disturbances. METHODS: Fifty patients with gastroesophageal reflux disease were studied, including 25 with vocal disturbances (group 1 - G1) and 25 without these symptoms (group 2 - G2). All patients were submitted to endoscopy, manometry and esophageal pHmetry (2 probes). The group 1 patients were submitted to videolaryngoscopy. RESULTS: Endoscopic findings: non-erosive reflux disease was observed in 95% of G1 patients and 88% of G2. Videolaryngoscopy: vocal fold congestion, asymmetry, nodules and polyps were observed in G1 patients. Manometric findings: pressure in the lower esophageal sphincter (mm Hg): 11.6 ± 5.2 in G1 and 14.0 ± 6.2 in G2 (P = 0.14); pressure in the upper esophageal sphincter (mm Hg): 58.4 ± 15.9 in G1 and 69.5 ± 30.7 in the controls. pHmetric findings: De Meester index: 34.0 ± 20.9 in G1 and 15.4 ± 9.4 in G2 (P<0.001); number of reflux episodes in distal probe: 43.0 ± 20.4 in G1 and 26.4 ± 17.2 in G2 (P = 0.003); percentage of time with esophageal pH value lower than 4 units (distal sensor): 9.0% ± 6.4% in G1 and 3.4% ± 2.1% in G2 (P<0.001); number of reflux episodes in proximal probe: 7.5 ± 10.9 in G1 and 5.3 ± 5.7 in G2 (P = 0.38); percentage of time with esophageal pH values lower than 4 units (Proximal probe): 1.2 ± 2.7 in G1 and 0.5 ± 0.7 in G2 (P = 0.21). CONCLUSIONS: 1) The clinical, endoscopic, and manometric findings observed in patients with vocal disturbance do not differ from those without these symptoms; 2) gastroesophageal reflux intensity is higher in patients with vocal disturbance; 3) patients without vocal disturbance can also present reflux episodes in the proximal probe.

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“…Według Jacoba, połowa chorych z objawami laryngologicznymi lub ze zmianami laryngoskopowymi doświadcza ekspozycji na kwas w proksymalnej części przełyku [75]. Ocenia się, Ŝe 4-10% pacjentów laryngologicznych ma objawy związane z GERD [76][77][78][79].…”

Section: G Epidemiologia I Symptomatologia Lprunclassified

“…Jak podaje Koufman, obrzęk nalewek obserwowany jest częściej niŜ zaczerwienienie. Obrzęk tylnego odcinka stwierdził on u 89% pacjentów a zaczerwienienie u 87%, ponadto tkankę ziarninową u 19% a owrzodzenie kontaktowe u 2% [77]. Zmiany w tylnym odcinku krtani najlepiej korelują z LPR, gdyŜ istnieje związek anatomiczny polegający na sąsiedztwie tylnego odcinka krtani z ustami przełyku.…”

Section: G Epidemiologia I Symptomatologia Lprunclassified

Zapalne i nowotworowe zmiany błony śluzowej krtani w chorobie refluksowej

Skrzypczak¹

2011

Otolaryngologia Polska

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Reflux laryngitis and its sequelae: The diagnostic role of ambulatory 24-hour pH monitoring

Cited by 117 publications

References 26 publications

The Reflux Finding Score: Reliability and Correlation to the Reflux Symptom Index

The Reflux Finding Score: Reliability and Correlation to the Reflux Symptom Index

Gastroesophageal reflux disease and vocal disturbances

Zapalne i nowotworowe zmiany błony śluzowej krtani w chorobie refluksowej

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