Reflux gastritis syndrome: Mechanism of symptoms

Meshkinpour, Hooshang; Marks, Jay W.; Schoenfield, Leslie J.; Bonnoris, George; Carter, Sylvia

doi:10.1016/0016-5085(80)90926-9

Cited by 34 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the 98 9R8c2 other hand, only three studies have directly examined the composition of reflux in any detail, and all confined themselves to an analysis of the individual bile acid species present. In two of these,20 22 in which a total of 17 asymptomatic and 25 symptomatic patients were evaluated, no marked difference could be detected between groups. The third report49 found a modest percentage of increase in the relative proportion of dihydroxy bile acids, particularly deoxycholate, in afflicted patients.…”

Section: Four Critical Questionsmentioning

confidence: 92%

“…It should be noted that the total number of patients involved was small, and estimation of bile acid concentration was made using samples of gastric juice obtained at endoscopy, a technique which has been shown to be unreliable. 18 A fifth study evaluated bile acid 22 concentration in upper intestinal content rather than in gastric juice. Significantly higher fasting levels were found in the intestinal aspirates of all symptomatic patients, although it was not shown that this material actually refluxed.…”

Section: Four Critical Questionsmentioning

confidence: 99%

See 1 more Smart Citation

Alkaline reflux gastritis: a critical reappraisal.

Ritchie¹

1984

Gut

View full text Add to dashboard Cite

Section: Four Critical Questionsmentioning

confidence: 92%

Section: Four Critical Questionsmentioning

confidence: 99%

Alkaline reflux gastritis: a critical reappraisal.

Ritchie¹

1984

Gut

View full text Add to dashboard Cite

“…These patients have been reported to have greater amounts of duodenogastric reflux than controls,8 14 and some surgeons have relied solely on evidence of DGR to select patients for remedial surgery. '6 Others have used provocation testing to identify those patients in whom DGR is actually responsible for symptoms.…”

Section: Discussionmentioning

confidence: 99%

Duodenogastric reflux after gastric surgery and in gastric ulcer disease: continuous measurement with a sodium ion selective electrode.

Smythe

O’Leary

Johnson

1993

Gut

View full text Add to dashboard Cite

Duodenogastric reflux (DGR) was investigated with a sodium ion selective electrode in 10 normal controls, 10 patients with persistent pain after gastric surgery, and five patients with gastric ulcer. During an average study time of two and a half hours, normal controls had reflux for 12% of the study, whereas patients after gastric surgery had reflux for 91% of the study time (p<00002). Patients with a gastric ulcer had reflux on average for 67% of the study (p<0001). The patients who had had gastric surgery had several symptoms, but there was no association between the number or nature of symptoms and the severity of DGR as determined by the sodium electrode. Patients with positive bile provocation tests did not show any significant difference in the duration of reflux compared with those with a negative provocation test (79% and 87%). There was also no relation between the results of the provocation test and the number and nature of symptoms. Continuous monitoring of intragastric sodium ions with a selective electrode is a practical means of assessing DGR. Results suggest that symptoms due to DGR may be related to the sensitivity of the gastric lining as well as the amounts of duodenal contents flowing back into the stomach.

show abstract

“…Bile alone but particularly in the presence of pepsin and acid can damage the gastroesophageal mucosa (6,20,22,24). Lycolecithin and pancreatic juice induce destruction in experimental conditions and probably also in humans (25,26).…”

Section: Disctjssionmentioning

confidence: 99%

“…The relationship between gastritis and duodenogastric reflux has rarely been examined in subjects with an unoperated stomach (11,24) but more often in subjects who have undergone partial gastrectomy (26)(27)(28)(29)(30). After gastric surgery both the bile reflux and the rapid development of chronic gastritis in the gastric remnant are common phenomena.…”

Section: Disctjssionmentioning

confidence: 99%

Chronic Gastritis in Cholecystectomized Patients

Hyvärinen

Sipponen

Kekki

1987

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

Duodenogastric reflux is considered to be a possible cause of chronic gastritis. This reflux, however, is reported to be common after cholecystectomy. In the present investigation we have studied the possible relation between chronic gastritis and prior cholecystectomy in 106 symptomatic outpatients with prior cholecystectomy and in 131 controls without cholecystectomy. We surveyed their endoscopic biopsy specimens from antral, body, and esophageal mucosa. We found that the mean score and prevalence of chronic antral and body gastritis in cholecystectomized patients was the same as or slightly lower than that in controls. The mean progression of gastritis, when compared with the progression of gastritis in the general population, was slightly slower than expected in the cholecystectomized patients. This slow progression was seen in body gastritis in cholecystectomized patients with a coexisting esophagitis. We conclude that there is no positive correlation between chronic gastritis and prior cholecystectomy. In contrast, this correlation may be negative, especially in patients with esophagitis, in whom an association of the postcholecystectomy state and a possible duodenogastric reflux with normal, nongastritic and nonatrophic body mucosa may facilitate mechanisms favoring the pathogenesis of esophagitis.

show abstract

Reflux gastritis syndrome: Mechanism of symptoms

Cited by 34 publications

References 15 publications

Alkaline reflux gastritis: a critical reappraisal.

Alkaline reflux gastritis: a critical reappraisal.

Duodenogastric reflux after gastric surgery and in gastric ulcer disease: continuous measurement with a sodium ion selective electrode.

Chronic Gastritis in Cholecystectomized Patients

Contact Info

Product

Resources

About