Reflux as an etiological factor of carcinoma of the laryngopharynx

Ward, Paul H.; Hanson, David G.

doi:10.1288/00005537-198811000-00009

Cited by 175 publications

(102 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…-Gastropharyngeal reflux: Gastroesophageal reflux has been related to increased risk of laryngeal SCC, especially among patients who lack other major risk factors (83). Gastroesophageal reflux may act as a promoter in the presence of tobacco and alcohol (84).…”

Section: -Diet and Nutritional Factorsmentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Abstract.Background: Multi-step cancerogenesis guides laryngeal cancer onset and it includes a wide variety of pre-cancerous lesions that are macroscopically challenging to identify and distinguish from initial cancerous foci. Since the treatment of laryngeal cancer and its precursor lesions has a great impact on important laryngeal basic functions, early detection and preoperative assessment are important for a curative and function-preserving therapy. Nowadays, despite the high number of more advanced diagnostic techniques and methods, unfortunately, it is not uncommon for different clinicians to use different nomenclature or to identify different stage for the same laryngeal lesion. From these observations, it is obvious that an instrument offering the possibility to detect precancerous lesions, early cancerous lesions, and satellite foci or second primaries would be the key to improving management and outcome in laryngeal patients. Object. Different modalities of diagnostic techniques of laryngeal lesions exist. Rather than difference between benign and obvious malignant diseases, more difficult is to detect the presence of precancerous epithelial alterations. Not all tests achieve the same diagnostic accuracy, hence this meta-analysis of literature aimed to synthesize the validity of each single diagnostic technique in identifying and staging laryngeal disease. Methods: A systematic review of literature was led searching for articles mentioning the following terms including their various combinations to maximize the yield: larynx, laryngeal precancerous lesions, laryngeal cancer, white light (WL) endoscopy, stroboscopy, contact endoscopy (CE), autofluorescence (AF), ultrasound (US), narrow band imaging (NBI), computed axial tomography (CAT), magnetic resonance imaging (MRI), positron emission tomography (PET), CAT/PET. Then, a quantitative analysis was carried on for paper published after 2005 onward, reporting a minumun series of 10 patients each study, declaring sensitivity and specificity of each diagnostic system. Results: The search identified 7215 publications, of which 3616 published after 2005, with a final results of a total of 214 articles stratified and included by our selection criteria. 42 out of 214 articles were selected for quantitative synthesis. 25 out of 41 studies had a quality score of ≥ 6 (good), 16 presented a score between 4 and 5 (fair). While objections can be raised about the pooling of different diagnostic procedures under the same group and the high level of heterogeneity in the meta-analyses, the inclusion of over 4400 laryngeal lesions makes the results fairly robust. Conclusions: A comprehensive overview of the most recent advances in laryngeal imaging technology combined with all of the information needed to interpret findings and successfully manage patients with voice disorders can be found herein. With these data, clinicians can riskstratify patients and select proper examination modalities in order to provide appropriate care. Moreover, study limitations, together with p...

show abstract

Section: -Diet and Nutritional Factorsmentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

show abstract

“…In 1976, it was first suggested that inflammatory disease could cause laryngeal cancer (23), and in the late 1980s, it was further proposed that gastroesophageal reflux could play a causal role in laryngeal and pharyngeal carcinogenesis (14,17). Until recently, the only available data on this subject were from uncontrolled case series, of which some authors interpreted their data in favor of an association (13)(14)(15)(16)(17), others against (24). In 2001, the first controlled study addressing this issue was published in the form of a nested case-control study in the United States, demonstrating a moderately strong association between reflux-related inpatient discharge diagnoses and cancers both of the larynx and pharynx (18).…”

Section: Discussionmentioning

confidence: 99%

“…A link between gastroesophageal reflux and laryngeal and pharyngeal cancers has also been suggested, based on results from several case series (13)(14)(15)(16)(17). Recently, a 2-fold increased risk for each of these two tumors was found among persons with a history of gastroesophageal reflux disease in a nested case-control study conducted using the computerized database of veterans' hospitals across the United States (18).…”

Section: Introductionmentioning

confidence: 99%

No Association between Gastroesophageal Reflux and Cancers of the Larynx and Pharynx

Nilsson

Chow

Lindblad

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Purpose: To examine the proposed relation between gastroesophageal reflux disease and cancers of the larynx and pharynx. Experimental Design: A cohort of 66,965 patients with discharge diagnoses of heartburn, hiatal hernia, or esophagitis was identified in the Swedish Inpatient Register. We observed a total of 376,622 person-years in the cohort. Identification of laryngeal and pharyngeal cancers was achieved through the Swedish Cancer Register. Standardized incidence ratios, the ratio of the observed to the expected number of cancers, derived from the general Swedish population and adjusted for sex, age, and calendar year, was used to estimate the relative risk. Results: During follow-up, 30 cases of laryngeal and 31 cases of pharyngeal cancer were detected in the cohort. Slightly increased risks of laryngeal [relative risk, 1.6; 95% confidence interval (CI), 1.1-2.2] and pharyngeal carcinomas (relative risk, 1.9; 95% CI, 1.3-2.8) were observed in the total reflux cohort. After stratification to exclude cohort members with a diagnosis of alcoholism, no significant increase in the risk of laryngeal (relative risk, 1.3; 95% CI, 0.8-2.0) or pharyngeal carcinomas (relative risk, 1.0; 95% CI, 0.5-1.6) was found compared with the general population. Furthermore, there were no dose-response patterns of the risk for laryngeal and pharyngeal cancers with years of cohort follow-up, indicators of reflux severity, or specificity of reflux diagnosis.

show abstract

“…Indeed, LPR has also been implicated in the development of laryngeal carcinoma and stenosis, recurrent laryngospasm, and cricoarytenoid joint fixation, as well as with many other otolaryngology-related conditions, including globus pharyngeus, cervical dysphagia, and subglottic stenosis. [4][5][6][7][8][9]. Patients with "reflux laryngitis" (LPR) present with hoarseness, but almost two thirds deny ever having heartburn.…”

Section: Introductionmentioning

confidence: 99%

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Pullarat¹

2017

IOSR JDMS

View full text Add to dashboard Cite

Reflux as an etiological factor of carcinoma of the laryngopharynx

Cited by 175 publications

References 11 publications

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

No Association between Gastroesophageal Reflux and Cancers of the Larynx and Pharynx

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Contact Info

Product

Resources

About