Reflexes Evoked from Tracheobronchial Tree and Lungs

Coleridge, H. M.; Coleridge, J. C. G.

doi:10.1002/cphy.cp030212

Cited by 177 publications

(203 citation statements)

References 189 publications

Supporting

Mentioning

193

Contrasting

Unclassified

Order By: Relevance

“…However, many physiological and pathological conditions activate both groups of receptors (Coleridge & Coleridge, 1986; Widdicombe, 1986;Sant'Ambrogio, 1982. We have therefore tried to see how reflexes from lung C-fibre receptors interact with those from rapidly adapting receptors.…”

Section: Introductionmentioning

confidence: 99%

“…Many reviewers believe that cough is mediated by G. WIDDICOMBE rapidly adapting (irritant) receptors in the airway walls (Sant'Ambrogio, 1982 Coleridge & Coleridge, 1986; Widdicombe, 1986), but recently a number of authors have suggested that cough can be induced by stimulation of C-fibre receptors in the lungs or larynx (Collier & Fuller, 1984; Midgren, Simonsson & Persson, 1986;Paintal, 1986;Karlsson, 1987;Fuller, Dixon, Cuss & Barnes, 1987). The evidence for this view will be considered in the Discussion.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lung C‐fibre receptor activation and defensive reflexes in anaesthetized cats.

Tatár

Webber

Widdicombe

1988

The Journal of Physiology

170

113

View full text Add to dashboard Cite

SUMMARY1. With pentobarbitone-anaesthetized cats we have elicited cough reflexes from the tracheobronchial tree and the larynx, and the aspiration and sneeze reflexes from the nasopharynx and the nose respectively. The reflexes were induced by mechanical stimulation of the mucosa, before and during activation of pulmonary C-fibre receptors by intravenous injections of capsaicin or phenylbiguanide.2. During the 20-30 s apnoea due to C-fibre stimulation, the cough reflex from both sites and the sneeze reflex were completely abolished, whereas the aspiration reflex response was approximately halved. Reflex contractions of genioglossus muscle still occurred at this time, but were far weaker than in the control state. 3. During the rapid shallow breathing that immediately followed apnoea due to Cfibre receptor stimulation, the defensive reflexes recovered: the aspiration and sneeze reflexes fully and the cough reflexes to about half of the control response.4. Acute hypotension due to haemorrhage, of a size considerably greater than that due to stimulation of the pulmonary C-fibre receptors, caused no significant inhibition of the cough reflex from the tracheobronchial tree. 5. We conclude that the pulmonary C-fibre reflex powerfully inhibits airway defensive reflexes, and that its activation is unlikely to contribute positively to coughing induced by aerosols of capsaicin and similar agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lung C‐fibre receptor activation and defensive reflexes in anaesthetized cats.

Tatár

Webber

Widdicombe

1988

The Journal of Physiology

170

113

View full text Add to dashboard Cite

show abstract

“…Unfortunately, we were unable to reproduce these results in lambs; such discrepancies may be related to differences in species, maturation and/or the use of anesthetics, all of which have previously been shown to affect bronchopulmonary receptors (Coleridge HM and Coleridge JCG, 2011).…”

Section: 2-attempts At Selectively Blocking Rarsmentioning

confidence: 83%

“…The short burst of EaTA, disappearing well before the end of the inspiratory pressure plateau in nPSV (see figure 3 in Moreau-Bussière et al, 2007), does not suggest the involvement of SAR. While both RARs and CFEs are also stimulated by lung distension (Coleridge JCG and Coleridge HM, 1984;Coleridge HM and Coleridge JCG, 2011), our previous observation that stimulation of pulmonary CFEs in lambs triggers post-inspiratory EaTA (Diaz et al, 1999), together with the availability of our robust lamb model with blocked CFEs, prompted us to assess the potential involvement of CFEs in inspiratory laryngeal narrowing during nPSV. The present demonstration that CEFs are not involved leads us now to suggest that this inspiratory laryngeal narrowing most likely originates from RAR stimulation.…”

Section: 1-inspiratory Laryngeal Narrowing During Npsvmentioning

confidence: 99%

See 1 more Smart Citation

Laryngeal narrowing during nasal ventilation does not originate from bronchopulmonary C-fibers

Samson

Niane

Nault

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

We previously showed that nasal pressure support ventilation (nPSV) can lead to active inspiratory laryngeal narrowing, which originates from the stimulation of bronchopulmonary receptors. Among the three major types of bronchopulmonary receptors, which are variably stimulated by lung distension, C-fiber endings are remarkable, given that their stimulation can also trigger laryngeal closure. Taking advantage of our lamb model with blocked C-fibers, we aimed to assess whether bronchopulmonary C-fiber endings are involved in the active inspiratory laryngeal narrowing during nPSV. Nine lambs were surgically instrumented to assess states of alertness, electrical activity of a glottal constrictor (EaTA), respiratory movements and arterial blood gases. Forty-eight hours later, two polysomnographic recordings were performed during nPSV 15/4 cmH 2 O, before and after C-fiber blockade. During nPSV, blockade of C-fibers did not prevent inspiratory EaTA (present for 74 ± 41% of respiratory cycles vs. 64 ± 35%, p = 0.9). We conclude that active inspiratory laryngeal narrowing during nPSV does not originate from bronchopulmonary C-fiber endings.

show abstract

Morphology of pulmonary rapidly adapting receptor relay neurons in the rat

et al. 2001

View full text Add to dashboard Cite

The term rapidly adapting pulmonary stretch receptor (RAR) refers to one of the major pulmonary sensory receptors that responds to inflation and deflation of the lungs as well as to irritant stimuli with rapidly adapting irregular discharges. The functional role and central pathways are largely unknown. The aim of this study was to elucidate morphological characteristics of second-order neurons (RAR cells) activated by vagal afferent fibers originating from RARs. A mixture of horseradish peroxidase (HRP) and Neurobiotin was injected intracellularly into physiologically identified RAR cells in Nembutal-anesthetized, immobilized, and artificially ventilated Wister rats. Direct visualization of individual RAR cells (n = 12), including their somata, dendritic arborizations, and fine axonal branches with terminal boutons, was possible for the first time. Their somata were located in the commissural or medial subdivision of the nucleus of the solitary tract, caudal to the level of the area postrema. The RAR cells had, in addition to dendrites extending into the NTS area, one or two long dendrites extending laterally and/or ventrolaterally into the medullary reticular formation. The stem axons issuing from the RAR cells first coursed ventrolaterally toward the reticular formation in the vicinity of the ambiguus nucleus and then bifurcated into ascending and descending axons: three RAR cells possessed only ascending axons. Some of the ascending axons could be traced as far as the level of the facial nucleus and some of the descending axons beyond the spinomedullary junction. These ascending and/or descending axons gave off extensive axon collaterals distributing boutons within and in the vicinity of the ambiguus nucleus. These results, showing an anatomical substrate for the network implicated in RAR-evoked reflexes, provide useful clues for study of the RAR system.

show abstract

Reflexes Evoked from Tracheobronchial Tree and Lungs

Cited by 177 publications

References 189 publications

Lung C‐fibre receptor activation and defensive reflexes in anaesthetized cats.

Lung C‐fibre receptor activation and defensive reflexes in anaesthetized cats.

Laryngeal narrowing during nasal ventilation does not originate from bronchopulmonary C-fibers

Morphology of pulmonary rapidly adapting receptor relay neurons in the rat

Contact Info

Product

Resources

About