Reflex antidiuresis after occlusion of common carotid arteries in hydrated dogs

Perlmutt, Joseph H.

doi:10.1152/ajplegacy.1963.204.2.197

Cited by 20 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, according to the atrial receptor hypothesis the lowered atrial pressure should be associated with a reduced urine flow. The reflex pathway, suggested by the data of Dieter - 8 and Okada et al,-° should increase renal nerve activity during stellate stimulation and thus decrease rather than increase urine flow. …”

Section: Discussionmentioning

confidence: 94%

Contribution of Baroreceptors to the Control of Renal Function

Gilmore

1964

Circulation Research

View full text Add to dashboard Cite

Electrical stimulation of the left stellate ganglion of the dog is associated with an increase in urine flow, in electrolyte and total solute excretion, and in the renal clearance of inulin. These changes appear rapidly, are well maintained during prolonged stimulation, and stop soon after stimulation has ceased. The hemodynamic responses associated with these changes are an increase in arterial pulse pressure, an increase or no change in mean arterial blood pressure, and a decline in mean left atrial pressure. The diuretic response to stellate ganglion stimulation is diminished, but not abolished, by bilateral cervical vagotomy as are the changes in electrolyte excretion, total solute excretion, and the renal clearance of inulin. However, the hemodynamic responses are not greatly modified by cervical vagotomy. Vagotomy just above the diaphragm does not appear to modify these responses. The effect of vagotomy on the renal responses to stellate stimulation appears to be a result of sectioning baroreceptor afferent nerves which traverse the vagus nerves. The rapidity of the renal response to stellate stimulation, its temporal relation to the hemodynamic changes, and the effect of cervical vagotomy indicate that the diuresis is, to a large degree, secondary to withdrawal of renal sympathetic vasoconstrictor nerve discharge. The similarities between the renal responses to stellate stimulation and to intravenous infusions indicate that infusion diuresis may be mediated, at least in part, by the same mechanism. When renal blood flow is measured directly in the perfused kidney, carotid occlusion is associated with little change or with a decrease in renal blood flow at a time when renal arterial pressure increases. When renal blood flow is maintained constant in the perfused kidney, carotid artery occlusion is associated with an increase in renal arterial pressure. The intrarenal administration of the adrenergic blocking agent, phenoxybenzamine, can prevent the increase in renal vascular resistance during carotid occlusion indicating that it is due to an adrenergic mechanism. The renal pressure-flow curve is displaced down and to the right during carotid occlusion; autoregulation of renal blood flow is still observed, although at a lower level of blood flow. All these changes indicate that the primary renal response to carotid occlusion is vasoconstriction mediated by the renal sympathetic nerves. It is well-known that urine flow increases when renal arterial pressure is increased independent of a change in the activity of the renal vasoconstrictor nerves and independent of a change in renal blood flow. Consequently, the rise in arterial pressure associated with carotid occlusion can contribute directly to the response of the kidney to carotid occlusion. The variability of the changes in water and electrolyte excretion by the kidney during carotid occlusion may represent a varying contribution of direct and reflex mechanisms to the total response.

show abstract

Section: Discussionmentioning

confidence: 94%

Contribution of Baroreceptors to the Control of Renal Function

Gilmore

1964

Circulation Research

View full text Add to dashboard Cite

show abstract

“…Secondly, Perlmutt (1963) found that the antidiuresis was seen only when carotid occlusion was applied below the thyrocarotid junction, but not when the occlusion was applied above the thyrocarotid junction. However, this latter manoeuvre would be expected to increase the general systemic blood pressure, as before, and there would also be an increased pressure at the thyrocarotid junction, which according to the theory of Share (1965) and Perlmutt (1963) would cause a diuresis.…”

mentioning

confidence: 83%

“…However, it is unlikely that the responses seen in . (Share, 1965) and antidiuresis is only observed when the occlusion is applied below the level of the thyrocarotid artery junction (Perlmutt, 1963). But these two studies reported conflicting results.…”

mentioning

confidence: 99%

Effects of small changes in carotid sinus pressure on renal haemodynamics and function in dogs.

Karim

Poucher

Summerill

1989

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. In dogs anaesthetized with chloralose and artificially ventilated, the carotid sinuses were vascularly isolated and perfused with arterial blood. Mean aortic pressure was held constant at 111+ 2 mmHg (mean + S.E.M., n = 18) by means of a pressure bottle connected to the aorta and a Starling resistance. Both vagus nerves were sectioned in the neck and propranolol hydrochloride (1 mg kg-' h-1) or atenolol (0-5-4 mg kg-' h-1) was administered. The left and right renal blood flows were measured by electromagnetic flowmeters (wrap-round probes), glomerular filtration rate by creatinine clearance, urinary sodium by flame photometry and solute excretion by osmometry.2. In six dogs decreasing pressure in the isolated carotid sinuses from 119+4 to 78 + 3 mmHg (n = 9) resulted in significant decreases in renal blood flow by 18 + 3 % (P < 0-01), glomerular filtration rate by 41 + 9 % (P < 0-01), filtration fraction by 30+11% (P < 005), urine flow by 46+6% (P < 0001), sodium excretion by 46+9% (P

show abstract

“…Previous reports (1,2) indicate that reduced urine flow and free-water clearance resulted from occlusion of the carotid arteries below the junctions of the superior thyroid and common carotid arteries in hydrated dogs, whereas occlusion above innervated or below denervated junctions was ineffective. Since in all these instances the carotid sinus reflex was activated, the conclusion was drawn that the carotid sinus is not the receptor site involved in the initiation of the reflex antidiuresis.…”

mentioning

confidence: 87%

“…Mongrel carotid occlusion below the thyrocarotid junctions was the same as previously described (1). A femoral artery was cannulated for determining blood pressure with a Statham pressure transducer connected to a Grass ~o l ygraph, and an indwelling needle was placed in an external jugular vein for obtaining blood samples at 30-min intervals during subsequent clearance periods.…”

mentioning

confidence: 99%

Antidiuretic Response to Occlusion of Common Carotid Arteries in Hydrated Dogs with Transected Sinus Nerves

Griffin

Stewart

Perlmutt

1973

Experimental Biology and Medicine

View full text Add to dashboard Cite

Previous reports (1, 2) indicate that reduced urine flow and free-water clearance resulted from occlusion of the carotid arteries below the junctions of the superior thyroid and common carotid arteries in hydrated dogs, whereas occlusion above innervated or below denervated junctions was ineffective. Since in all these instances the carotid sinus reflex was activated, the conclusion was drawn that the carotid sinus is not the receptor site involved in the initiation of the reflex antidiuresis. Additional evidence for the validity of this conclusion is presented in the present report which concerns the effect of carotid occlusion below thyrocarotid junctions on several indices of renal function during water diuresis in dogs with transected sinus nerves.Methods. Mongrel dogs of both sexes (12.7-16.8 kg) , vaccinated against distemper and infectious hepatitis and treated for intestinal parasites, were deprived of food for 18 hr and anesthetized with intravenous pentobarbital sodium (30 mp/kg, with supplementation as required). After a priming intravenous injection of creatinine and p-aminohippurate (PAH), warm 3.5% glucose in water with sustaining amounts of these substances was infused intravenously by pump at a rate of 2.5 ml/min for the duration of the experiment. Preparation of animals for the collection of urine from cannulated ureters and for subsequent nontraumatic

show abstract

Reflex antidiuresis after occlusion of common carotid arteries in hydrated dogs

Cited by 20 publications

References 0 publications

Contribution of Baroreceptors to the Control of Renal Function

Contribution of Baroreceptors to the Control of Renal Function

Effects of small changes in carotid sinus pressure on renal haemodynamics and function in dogs.

Antidiuretic Response to Occlusion of Common Carotid Arteries in Hydrated Dogs with Transected Sinus Nerves

Contact Info

Product

Resources

About