2012
DOI: 10.1109/jsen.2012.2189382
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Reflective Diffraction Gratings From Hydrogels as Biochemical Sensors

Abstract: We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a stimuli-responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell/shrink reversibly due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's motions with nanoscale precision and resulted in a resolution of 6 × 10 −4 pH units. The developed system is remarkably simple both to fabricate and operate, and … Show more

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Cited by 17 publications
(14 citation statements)
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“…The disadvantage of grating-based sensors is that the light beam is incident through the sample solution usually, which may give some inaccuracies if the sample is absorptive [29][30][31]. In our proposal, the light is incident on the bottom grating, that does not have any interaction with an external medium (gas or liquid) filled in the gap and surface region of top grating, as shown in the inlet in Fig.…”
Section: Sensing Performance Analysismentioning
confidence: 99%
“…The disadvantage of grating-based sensors is that the light beam is incident through the sample solution usually, which may give some inaccuracies if the sample is absorptive [29][30][31]. In our proposal, the light is incident on the bottom grating, that does not have any interaction with an external medium (gas or liquid) filled in the gap and surface region of top grating, as shown in the inlet in Fig.…”
Section: Sensing Performance Analysismentioning
confidence: 99%
“…They measure the pH value of a given fluid by observing optical parameters such as absorption, reflection, transmission of optical power, and fluorescence. On the other hand, wavelength-modulated pH sensors use a pH-sensitive hydrogel with an optical-fiber Bragg grating [36], a long period grating [37], or a reflective diffraction grating [38]. Constructing intensity-modulation pH sensors is easy, but their sensitivity is low, and fluctuations in the light intensity affect the pH measurement.…”
Section: Introductionmentioning
confidence: 99%
“…More recently, environmentally sensitive hydrogels used as smart chemo-mechanical transducers have been exploited to fabricate passive wireless chemical sensors using MEMS technology [2][3][4]. These smart polymeric materials having a reversible swelling/shrinking behavior in response to physiological parameters such as pH, temperature, and blood glucose can be utilized in various biomedical applications as actuators, chemical sensors, and drug delivery systems [5][6][7][8][9].…”
Section: Introductionmentioning
confidence: 99%