Reflections on the Predictability of Evolution: Toward a Conceptual Framework

Mas, Alix; Lagadeuc, Yvan; Vandenkoornhuyse, Philippe

doi:10.1016/j.isci.2020.101736

Cited by 12 publications

(15 citation statements)

References 71 publications

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“…Public health threats from rapidly evolving pathogens, together with observations of convergent and parallel evolution, have stimulated recent efforts to explore the predictability of evolutionary processes [1][2][3][4][5]. Yet, even our understanding of the contribution of fundamental mechanisms, such as mutation and selection, to parallel evolution in laboratory evolution experiments with asexual microbes is incomplete [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

et al. 2022

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Mutations with large fitness benefits and mutations occurring at high rates may both cause parallel evolution, but their contribution is predicted to depend on population size. Moreover, high-rate and large-benefit mutations may have different long-term adaptive consequences.We show that small and 100-fold larger bacterial populations evolve resistance to a β-lactam antibiotic by using similar numbers, but different types of mutations. Small populations frequently substitute similar high-rate structural variants and loss-of-function point mutations, including the deletion of a low-activity β-lactamase, and evolve modest resistance levels.Large populations more often use low-rate, large-benefit point mutations affecting the same targets, including mutations activating the β-lactamase and other gain-of-function mutations, leading to much higher resistance levels. Our results demonstrate the separation by clonal interference of mutation classes with divergent adaptive consequences, causing a shift from high-rate to large-benefit mutations with increases in the population size.

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Section: Introductionmentioning

confidence: 99%

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

et al. 2022

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“…Predicting phenotypic evolution is an important but challenging problem in the eld of evolutionary biology (43)(44)(45). Further research on the mechanisms of phenotypic stability and robustness, and on how these factors promote evolutionary conservation will contribute to the development of an evolutionary theory of phenotypic predictability.…”

Section: Discussionmentioning

confidence: 99%

Stability in gene expression and body-plan development leads to evolutionary conservation

Uchida

Takeda

Furusawa

et al. 2022

Preprint

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Background: Phenotypic evolution is mainly explained by selection for phenotypic variation arising from factors including mutation and environmental noise. Recent theoretical and experimental studies in the medaka fish Oryzias latipes suggest that greater developmental stability in phenotype and gene expression level, observed under conditions of minimal mutation and environmental noise, is positively correlated with intra-specific evolutionary conservation. Therefore, stability would be a novel intrinsic factor that potentially limits phenotypic variation, promoting evolutionary conservation. However, while these prior studies have revealed correlative relationships between stability and evolutionary conservation, the issue of causality has remained unclear. Here, in Japanese medaka, we tested experimentally whether greater stability in phenotype and gene expression leads to evolutionary conservation. Results: Experimental evolution was performed by crossing distantly related Japanese medaka lines, followed by two rounds of intra-generational crossing. We then analyzed whether more stable developmental stages and genes with more stable expression in the F0 generation were more conserved in the F3 generation. The results indicated that greater stability in the F0 generation led to less diversity in the F3 generation. Conclusions: These findings reveal that stability in phenotype and gene expression leads to theirevolutionary conservation, most likely by reducing the potential for phenotypic variation. Further, among the developmental stages, the body-plan-establishment stage exhibited the greatest stability and conservation, potentially contributing to the strict conservation of animal body plan.

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“…How predictable is evolution? This question has intrigued evolutionary biologists for over a century [1][2][3][4], and although much progress has been made towards answering it, more remains to be learned about conditions and processes influencing the degree of predictability in evolutionary responses [5][6][7][8]. Understanding when and why evolution is predictable is not only of pure academic interest but also of practical utility.…”

Section: Introductionmentioning

confidence: 99%

Age-dependent genetic architecture across ontogeny of body size in sticklebacks

Fraimout

Sillanpää

et al. 2022

Proc. R. Soc. B.

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Heritable variation in traits under natural selection is a prerequisite for evolutionary response. While it is recognized that trait heritability may vary spatially and temporally depending on which environmental conditions traits are expressed under, less is known about the possibility that genetic variance contributing to the expected selection response in a given trait may vary at different stages of ontogeny. Specifically, whether different loci underlie the expression of a trait throughout development and thus providing an additional source of variation for selection to act on in the wild, is unclear. Here we show that body size, an important life-history trait, is heritable throughout ontogeny in the nine-spined stickleback ( Pungitius pungitius ). Nevertheless, both analyses of quantitative trait loci and genetic correlations across ages show that different chromosomes/loci contribute to this heritability in different ontogenic time-points. This suggests that body size can respond to selection at different stages of ontogeny but that this response is determined by different loci at different points of development. Hence, our study provides important results regarding our understanding of the genetics of ontogeny and opens an interesting avenue of research for studying age-specific genetic architecture as a source of non-parallel evolution.

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Reflections on the Predictability of Evolution: Toward a Conceptual Framework

Cited by 12 publications

References 71 publications

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

Stability in gene expression and body-plan development leads to evolutionary conservation

Age-dependent genetic architecture across ontogeny of body size in sticklebacks

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