Reflections of six neuroscientists: The influences of training at minority serving institutions

Grillo, Wendy H.; Boateng, Comfort A.; Brady, Lillian J.; Gaudier-Diaz, Monica M.; Mitchell, Kerry Ann; Ruffin, Vernon A.; Tejdeda, Hugo A.; Marshall, S. Alex

doi:10.1002/jnr.24796

Cited by 2 publications

(2 citation statements)

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“…The mechanobiology of the ECM is mediated by interactions between the ECM and the cytoskeleton of cells (Hall et al, 2021; Kim & Nelson, 2012; Procès et al, 2022; Tyler, 2012). The cytoskeleton of neural cells connects to the ECM at focal adhesion complexes via transmembrane integrin receptors, which transmit forces from the ECM to the interior of the cell and vice versa (Dobrynina et al, 2020; Grillo et al, 2022; Schwanstecher & Schwanstecher, 2015) (Figure 2). Through this pathway, mechanical stimuli can modulate a variety of functions in neurons and glia, including growth cone mechanosensing, traction force generation, axon guidance, stem cell differentiation, and synapse maintenance (Hall et al, 2021; Martino et al, 2018; Procès et al, 2022; Tyler, 2012).…”

Section: The Ecm In Cnsmentioning

confidence: 99%

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

Ortega,

Soares de Aguiar,

Chandravanshi

et al. 2024

WIREs Nanomed Nanobiotechnol

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The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules that surrounds cells and tissues in the nervous system and orchestrates a myriad of biological functions. This review carefully examines the diverse interactions between cells and the ECM, as well as the transformative chemical and physical changes that the ECM undergoes during neural development, aging, and disease. These transformations play a pivotal role in shaping tissue morphogenesis and neural activity, thereby influencing the functionality of the central nervous system (CNS). In our comprehensive review, we describe the diverse behaviors of the CNS ECM in different physiological and pathological scenarios and explore the unique properties that make ECM‐based strategies attractive for CNS repair and regeneration. Addressing the challenges of scalability, variability, and integration with host tissues, we review how advanced natural, synthetic, and combinatorial matrix approaches enhance biocompatibility, mechanical properties, and functional recovery. Overall, this review highlights the potential of decellularized ECM as a powerful tool for CNS modeling and regenerative purposes and sets the stage for future research in this exciting field.This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Implantable Materials and Surgical Technologies > Nanomaterials and Implants

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Section: The Ecm In Cnsmentioning

confidence: 99%

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

Ortega,

Soares de Aguiar,

Chandravanshi

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…To start this special issue, we have included the reflections of neuroscientists who received training at an MSI and have continued their contribution to the field as researchers, clinicians, and teachers (Grillo et al, 2021). There are also two commentaries on the efforts within academic (Harrington, 2021) and governmental institutions (Jones et al, 2021) to improve diversity in the workforce.…”

mentioning

confidence: 99%