Reflection Magnitude, a Measure of Arterial Stiffness, Predicts Incident Heart Failure in Men But Not Women: Multi-Ethnic Study of Atherosclerosis (MESA)

Chester, Rebecca; Gornbein, Jeff; Hundley, W. Gregory; Srikanthan, Preethi; Watson, Karol E.; Horwich, Tamara B.

doi:10.1016/j.cardfail.2017.01.002

Cited by 17 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A time‐resolved wall stress curve allows for characterization of the myocardial loading sequence, which can be expressed as a ratio of the stress‐time integral in late vs. early systole. A high late‐to‐early systolic stress time integral ratio has been shown to be associated with reduced indices of myocardial systolic contraction and diastolic relaxation and left atrial dysfunction, providing a link between wave reflections and the reported risk of incident HF in the general population ( Figure H–I ).…”

Section: Methods To Assess Ventricular–arterial Couplingmentioning

confidence: 98%

See 1 more Smart Citation

The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

Ikonomidis

Aboyans

Blacher³

et al. 2019

European J of Heart Fail

235

243

View full text Add to dashboard Cite

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment possesses independent diagnostic and prognostic value and may be used to refine riskstratification and monitor therapeutic interventions. Traditionally, VAC is assessed by the non‐invasive measurement of the ratio of arterial (Ea) to ventricular end‐systolic elastance (Ees). With disease progression, both Ea and Ees may become abnormal and the Ea/Ees ratio may approximate its normal values. Therefore, the measurement of each component of this ratio or of novel more sensitive markers of myocardial (e.g. global longitudinal strain) and arterial function (e.g. pulse wave velocity) may better characterize VAC. In valvular heart disease, systemic arterial compliance and valvulo–arterial impedance have an established diagnostic and prognostic value and may monitor the effects of valve replacement on vascular and cardiac function. Treatment guided to improve VAC through improvement of both or each one of its components may delay incidence of heart failure and possibly improve prognosis in heart failure. In this consensus document, we describe the pathophysiology, the methods of assessment as well as the clinical implications of VAC in cardiac diseases and heart failure. Finally, we focus on interventions that may improve VAC and thus modify prognosis.

show abstract

Section: Methods To Assess Ventricular–arterial Couplingmentioning

confidence: 98%

“…Normal values for PWV (< 10/ms) and central systolic BP (< 130 mmHg) have been described and their predictive value for incident cardiovascular mortality and HF has been demonstrated ( Table ) …”

Section: Methods To Assess Ventricular–arterial Couplingmentioning

confidence: 99%

The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

Ikonomidis

Aboyans

Blacher³

et al. 2019

European J of Heart Fail

235

243

View full text Add to dashboard Cite

show abstract

“…In the clinic, non-invasive methods are increasingly applicable and three techniques can be used: assessment of distensibility (given by simultaneous measurement of intravascular volume and pressure), 21 arterial pulse waveform analysis (arterial tonometry), 22 and measurement of PWV. The latter, according to consensus, is the gold standard method for measuring arterial stiffness.…”

Section: Evaluation Of Arterial Stiffness and Cardiometabolic Phenotypesmentioning

confidence: 99%

Arterial Stiffness: Pathophysiological and Genetic Aspects

Alvim

Santos

Bortolotto

et al. 2017

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) are the main cause of mortality and it represents a significant percentage of hospitalizations. In the scenario of minimization of costs of the health system, methods that identify subclinical CVD would be important. Some guidelines include the measures of aortic stiffness and intima-media thickness of the carotid artery as methods to identify subclinical CVD in hypertensive patients. The pulse wave velocity (PWV) is the gold standard for the evaluation of arterial stiffness. In this review, we report the pathophysiology, the determinants of arterial stiffness, and justify its inclusion in the assessment of hypertensive patient due its direct association with cardiovascular risk, as show in the I Diretriz Brasileira de Prevenção Cardiovascular. In addition, we raised the main genetic studies of this phenotype, due to its complexity, can be modulated by dozens of genes. However, a better understanding of the relationship genetic-arterial stiffness and, even an intervention based on genotypes, should be achieved in future studies.

show abstract

“…Lastly, arterial stiffness has been consistently associated with cardiovascular disease. Although earlier studies of the association of arterial stiffness with heart failure were negative, recent data from MESA (54, 55) and the Framingham Heart Study (56) have demonstrated an independent association of PWV with incident heart failure. Currently, no definitive data exist to compare the associations of PWV and heart failure with preserved ejection fraction versus reduced ejection fraction.…”

Section: Importance Of Arterial Stiffening – Effects On End-organsmentioning

confidence: 96%

Determinants of Vascular Age: An Epidemiological Perspective

2019

View full text Add to dashboard Cite

Background: Vascular age is an emerging health indicator and predictor of end-organ damage to the heart, brain, and kidney. Although there have been many review publications concerning risk factors for vascular aging, most include cross-sectional epidemiological studies, limiting inferences about temporality. There is a need for a review of longitudinal epidemiological studies with repeat measures of vascular structure and function to allow for a systematic examination of determinants of vascular age and the association of vascular aging with outcomes. Content: Arterial stiffness is the most frequently used measure of vascular aging. We report here results of an extensive literature review of longitudinal cohort studies with repeat measures of arterial stiffness to characterize determinants of vascular age. Additionally, we summarize population-based studies which have focused on the association of arterial stiffness with end-organ damage and adverse cardiovascular outcomes. Summary: Changes in arterial stiffness are evident in early childhood. In adults, arterial stiffness has been observed to progress at the average rate of 0.2–0.7 meters per second for every five years of life. The state of the science is limited by the small number of studies with repeat measures of arterial stiffness and determinants of arterial stiffness progression, as well as limited studies in children and diverse race/ethnic groups. Several extant studies suggest that beyond age, cardiometabolic risk factors and adverse lifestyle behaviors contribute to arterial stiffening. Arterial stiffness is therefore, important in the assessment of healthy vascular aging and a possible target for the prevention of subclinical and clinical disease.

show abstract

Reflection Magnitude, a Measure of Arterial Stiffness, Predicts Incident Heart Failure in Men But Not Women: Multi-Ethnic Study of Atherosclerosis (MESA)

Cited by 17 publications

References 43 publications

Arterial Stiffness: Pathophysiological and Genetic Aspects

Determinants of Vascular Age: An Epidemiological Perspective

Contact Info

Product

Resources

About