Reflectance confocal microscopy characteristics for melanocytic nevi

Yan, Jing; Shen, Changbing; Xue, Ke; Li, Chengxu; Shen, Xue; Wang, Ziyi; Xu, Feng; Meng, Rusong; Cui, Yong

doi:10.1097/cm9.0000000000000440

Cited by 4 publications

(6 citation statements)

References 5 publications

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“…The cell sizes were roughly uniform. Our findings were consistent with previously reported IVCM images of dermal melanocytic nevi ( 12 ). However, they differed from IVCM images of conjunctival nevi, which have been found to exhibit lower reflectivity than the surrounding tissue ( 9 ).…”

Section: Discussionsupporting

confidence: 94%

“…Third, the resolution of IVCM is not comparable to that of conventional histopathological sections, although IVCM is non-invasive, real-time, and dynamic as compared to traditional histopathology, which is time-consuming and invasive. In addition, the examination process for IVCM requires the cooperation of the patient ( 12 ). Finally, IVCM is not able to distinguish activated Langerhans cells from dendritic melanocytes, since both are cells with prominent dendritic processes and they share similar refractive indices and morphological features.…”

Section: Discussionmentioning

confidence: 99%

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Morphological characterization of nevi on the caruncle conjunctiva under in vivo confocal microscopy

Cai

et al. 2023

Front. Med.

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ObjectiveThis study aimed to investigate the microscopic structure and characteristics of nevi on the conjunctiva of the lacrimal caruncle by in vivo confocal microscopy.MethodsIn total, four patients with nevi growing on the lacrimal caruncle conjunctiva were recruited. The morphological characteristics of the nevi were evaluated by in vivo confocal microscopy before excision surgery; the results were compared with histopathological analyses of the surgical specimens.ResultsThe nevi of the four patients were all located at the conjunctiva of the lacrimal caruncle, with a slightly nodular surface, mixed black and brown color, and clear boundary. The nevi were round and highly protruded on the surface of the lacrimal caruncle, with an average diameter of 4.5 ± 1.29 mm. Under in vivo confocal microscopy, the pigmented nevus cells on the conjunctiva of the lacrimal caruncle were observed to be clustered in nests with irregular boundaries. The cells were round or irregular, with clear cell boundaries, hyper-reflective at the periphery, with low reflectivity in the center. Vascular crawling was observed in some regions. Histopathological analysis showed that nevus cells were roughly equal in size and distributed in a nodular pattern. Melanin granules were observed in the cytoplasm. No atypia or mitotic figures of the cells were found.ConclusionThis study revealed that the microstructure of nevi growing on the conjunctiva of the lacrimal caruncle can be identified by in vivo confocal microscopy.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Morphological characterization of nevi on the caruncle conjunctiva under in vivo confocal microscopy

Cai

et al. 2023

Front. Med.

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“…SN are benign melanocytic lesions mostly identified by characteristic clinical and dermoscopic features. Although histopathological and dermoscopic criteria of SN have been considerably described, differential diagnosis of SN and MM is challenging [ 12 – 14 ]. In our study, most SN and MM in dermoscopy presented a “starburst” type of architecture ( Figure 4 A ).…”

Section: Discussionmentioning

confidence: 99%

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Pogorzelska-Antkowiak¹,

Słowińska²,

Farinazzo³

et al. 2023

pdia

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Introduction: Spitz nevi (SN) include a wide range of benign melanocytic nevi, which are controversial due to their morphologic resemblance to melanoma (MM). Aim: To describe dermoscopic and reflectance confocal microscopic (RCM) features of SN compared to MM and assess the RCM utility in the differential diagnosis. Material and methods: We performed a multicentre retrospective analysis of MM and SN evaluated with dermoscopy and reflectance confocal microscopy. Three RCM mosaics were obtained for each lesion. Nine dermoscopic and twenty-one microscopic features were assessed for each lesion. Results: A total of 26 lesions (15 SN and 11 MM) were included. Dermoscopically, most SN showed a "starburst" pattern. Asymmetry was marked in 8 MM. There were 6 dermoscopic features significantly more prevalent in MM than in SN. RCM showed that an atypical honeycomb pattern, atypical infiltration, and disarray of the epidermis were significant for MM. SN mostly revealed a typical honeycomb pattern. At the DEJ, most of SN had a meshwork pattern; MM revealed an atypical meshwork pattern. Atypical cells and sheet-like structures were observed in most MM. Conclusions: A combined approach using dermoscopy and RCM supports the differential diagnosis of SN and MM. Although our study showed some significant differences between SN and MM in RCM, further research on a larger group should be considered.

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“…At present, the widely recognized RCM standards for pigmented nevus include the following: well circumscribed and symmetrical; normal honeycomb and cobblestone patterns of the epidermis; clearly defined dermal‐epidermal junction; uniformly sized and shaped dermal papillary rings; and dense, homogeneous cell clusters, uniform in size and shape, and even in distribution 3‐5,15 . This study analyzed the RCM images of clinically diagnosed pigmented nevus, aiming to evaluate the application of RCM in the diagnosis of pigmented nevus and explore its challenges in the diagnosis and differential diagnosis of pigmented nevus.…”

Section: Discussionmentioning

confidence: 99%

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus

Tang

Huang

et al. 2020

Skin Research and Technology

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Pigmented nevus is a benign tumor composed of nests of melanocytes. From infants to the elderly, almost everyone has it. It can grow in any part of normal people. Based on different locations of melanocytes in the skin, pigmented nevus can be classified into junctional nevus, compound nevus, and intradermal nevus. Some grow on the head and face or the limbs which affect the appearance, while some grow in such friction-prone parts as the palm, sole, neck or back. If the pigmented nevus increases significantly in a short period of time, or leads to itching, burning, inflammation, bleeding, ulceration, etc, it indicates the nevus has a certain tendency for deterioration or may have turned canceration. Clinically, it should be distinguished from many other diseases such as seborrheic keratosis (SK), warts, basal cell carcinoma (BCC), and malignant melanoma (MM), 1 and its diagnosis is usually based on histological examination of skin biopsy. Reflectance confocal microscopy (RCM) is a new non-invasive method based on optical confocal principle with advantages of in situ, in vivo, non-invasive, dynamic, etc. 2 Some studies have described the characteristics of RCM images of pigmented nevus. It usually shows a clear and symmetrical border of the lesion, regular arrangement of the

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Reflectance confocal microscopy characteristics for melanocytic nevi

Cited by 4 publications

References 5 publications

Morphological characterization of nevi on the caruncle conjunctiva under in vivo confocal microscopy

Morphological characterization of nevi on the caruncle conjunctiva under in vivo confocal microscopy

Spitz nevus and melanoma: evaluation with dermoscopy and reflectance confocal microscopy

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus

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