2021
DOI: 10.1038/d41586-021-03000-9
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Refining the toolkit for sugar analysis

Abstract: ugars are everywhere in biology. They decorate cells, proteins and lipids. According to a surprise finding, published in June, they even adorn RNAs 1 . Yet these carbohydrates, also called glycans, have garnered little attention in recent decades."Glycans form an essential biological language, the glycome," says Mark von Itzstein,

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Cited by 4 publications
(5 citation statements)
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“…One major obstacle in this direction is that, there is no established method to generate an antibody that recognizes a glycotope displayed on a specific protein scaffold. Technological breakthroughs and a platform enabling the development of such antibodies are highly anticipated (43).…”
Section: Discussionmentioning
confidence: 99%
“…One major obstacle in this direction is that, there is no established method to generate an antibody that recognizes a glycotope displayed on a specific protein scaffold. Technological breakthroughs and a platform enabling the development of such antibodies are highly anticipated (43).…”
Section: Discussionmentioning
confidence: 99%
“…The negative effects of antibiotics are taken into serious consideration because of their inducement of long-term microbiota change, allergic symptoms, metabolic, immunological and inammatory dysfunctions. 4 As a vegetable, jute leaves are traditionally used to treat constipation, dysentery and dyspepsia. 22 Therefore, the potential biological protective effects of jute NCC on human gut bacteria were investigated.…”
Section: Protective Function Of Ncc On Human Gut Bacteria In Vitromentioning
confidence: 99%
“…There was another report that some plant functional components taken regularly might protect bacteroides species in human gut microbiota from erythromycin more effectively. 4 However, kanamycin treatment inhibited the growth of L. rhamnosus but did not kill the cell. A high concentration of jute cellulose (5 and 50 mg mL −1 ) signicantly inhibited the growth of L. rhamnosus under kanamycin treatment, while a high NCC concentration of 50 mg mL −1 had a slight potential protection effect on L. rhamnosus under kanamycin treatment at the time points of 8, 16, 24, and 32 h (P < 0.05) (Fig.…”
Section: Protective Function Of Ncc On Human Gut Bacteria In Vitromentioning
confidence: 99%
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“…Yet remarkable advances are continuously made in the development of new high-precision tools and techniques [16][17][18][19][20][21][22][23][24][25][26] that allow us to shed light on different aspects of the glycome. Within this framework, the potentials of glycobioinformatics [27][28][29][30][31][32] databases and resources and of high-performance computing (HPC) molecular simulations 7,8 are extraordinary, especially within a context where information from multiple sources is required to decipher the GlycoCode 33 . Here we introduce GlycoShape (https://glycoshape.org) an open access (OA) web-based platform designed to supplement the missing 3D structural information on glycans and glycoproteins, leveraging on over 1 ms of molecular dynamics (MD) simulations ran in dilute solution at standard conditions of temperature, pressure and salt concentration.…”
Section: Introductionmentioning
confidence: 99%