Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction
Jeanne E. Savage,
Christiaan A. de Leeuw,
Josefin Werme
et al.
Abstract:Background: Gene-environment interaction (GxE) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we utilize a series of genome-wide gene-environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM. Methods: We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with tra… Show more
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